Sökning: "foam cell formation"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden foam cell formation.

  1. 1. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Azra Alajbegovic; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2019]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Vascular smooth muscle cells VSMC ; cell phenotype; microRNA; Aneurysm; hypertension; Actin polymerization; GATA6; MRTFA; Vascular disease;

    Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER

  2. 2. Lipid storage and secretion. Studies on VLDL assembly and foam cell formation

    Detta är en avhandling från Lund University: Faculty of Medicine

    Författare :Björn Magnusson; Göteborgs universitet.; Gothenburg University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADP-ribosylation factor 1; very low density lipoprotein; lipid droplet; adipocyte differentiation-related protein; hypoxia; foam cell;

    Sammanfattning : This thesis deals with formation of two factors of upmost importance for the development of atherosclerosis: the triglyceride rich very low density lipoproteins 1 (VLDL1) and the lipid loaded macrophages ("foam cells"- characteristic features of the atherosclerotic lesion). Both these processes depend on the cellular accumulation of lipids. LÄS MER

  3. 3. Studies on receptors for modified LDL in human monocytes and macrophages : a link between diabetes and atherosclerosis?

    Detta är en avhandling från Göteborg : University of Gothenburg

    Författare :Linda Svensson; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atherosclerosis; diabetes CD14; CD36; CD64; fatty acid; flow cytometry; macrophage; monocyte; scavenger receptor;

    Sammanfattning : Type 2 diabetes increases the risk for cardiovascular disease three- to fourfold. Because of the rise in diabetes prevalence there is a need for a better understanding of the link between diabetes and atherosclerosis. LÄS MER

  4. 4. Intracellular lipids and inflammatory activity in macrophage foam cells

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Jenny Persson; Lund University.; Lunds universitet.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; lipid droplet; cytokine; inflammation; adipophilin; perilipin; atherosclerosis; Macrophage; foam cell;

    Sammanfattning : Cardiovascular disease (CVD) is characterized by lipid accumulation and inflammation in arteries. The disease starts early in life with migration of monocytes into the arterial wall where they engulf entrapped lipoproteins and become macrophage foam cell. LÄS MER

  5. 5. Studies on scavenger receptor class B type I and genes implicated in foam cell formation

    Detta är en avhandling från Göteborg

    Författare :Per-Arne Svensson; Göteborgs universitet.; Gothenburg University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; scavenger receptor class B type I; high-density lipoprotein; oxidized low-density lipoprotein; macrophages; expression profiling;

    Sammanfattning : The risk of atherosclerosis correlates with plasma levels of low-density lipoprotein (LDL) cholesterol and is inversely correlated to plasma levels of high-density lipoprotein (HDL) cholesterol. Accumulation of oxidized LDL (oxLDL) by arterial macrophages is a key event in the development of atherosclerosis. LÄS MER