Sökning: "flutemetamol"

Hittade 4 avhandlingar innehållade ordet flutemetamol.

  1. 1. Characterization of [18F]flutemetamol binding properties : A β-amyloid PET imaging ligand

    Författare :Kerstin Heurling; Mark Lubberink; Jens Sörensen; Julie Price; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography PET ; molecular imaging; amyloid; tracer validation; Radiology; Radiologi;

    Sammanfattning : The criteria for diagnosing Alzheimer’s disease (AD) have recently been revised to include the use of biomarkers for the in vivo presence of β-amyloid, one of the neuropathological hallmarks of AD. Examples of such biomarkers are positron emission tomography (PET) β-amyloid specific ligands, including [18F]flutemetamol. LÄS MER

  2. 2. [18F]Flutemetamol PET image processing, visualization and quantification targeting clinical routine

    Författare :Johan Lilja; Sörensen Jens; Mark Lubberink; Elna-Marie Larsson; Lars Olson; Claus Svarer; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; quantification; flutemetamol; amyloid imaging; Alzheimer’s disease; positron emission tomography; brain mapping; stereotactic surface projections; image registration; Computerized Image Processing; Datoriserad bildbehandling;

    Sammanfattning : Alzheimer’s disease (AD) is the leading cause of dementia and is alone responsible for 60-70% of all cases of dementia. Though sharing clinical symptoms with other types of dementia, the hallmarks of AD are the abundance of extracellular depositions of β-amyloid (Aβ) plaques, intracellular neurofibrillary tangles of hyper phosphorylated tau proteins and synaptic depletion. LÄS MER

  3. 3. Dynamics of proteinopathies in Alzheimer’s disease as measured by PET and CSF biomarkers

    Författare :Antoine Leuzy; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the extracellular aggregation of the amyloid-β (Aβ; amyloid) peptide and the intraneuronal accumulation of the protein tau. Independently, and in concert, these protein opathies lead to the loss of synapses and neurons (neurodegeneration). LÄS MER

  4. 4. Evaluation of Regularized Image Reconstruction for Clinical Positron Emission Tomography

    Författare :Elin Lindström; Mark Lubberink; Jens Sörensen; Anders Sundin; Anne Larsson Strömvall; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Positron emission tomography; PET CT; molecular imaging; image reconstruction; regularized reconstruction; quantification; oncology; neurology; cardiology; Medicinsk radiofysik; Medical Radiophysics;

    Sammanfattning : Positron emission tomography (PET) combined with computed tomography (CT) is a widely used noninvasive molecular imaging modality with a broad range of clinical applications in oncology, neurology, and cardiology. Producing imperative image quality and accurate quantification are important driving forces behind the technological advances within PET image reconstruction and system development. LÄS MER