Sökning: "fluorescence in-situ hybridization"

Visar resultat 1 - 5 av 54 avhandlingar innehållade orden fluorescence in-situ hybridization.

  1. 1. Telomere analysis of normal and neoplastic hematopoietic cells : studies focusing on fluorescence in situ hybridization and flow cytometry

    Författare :Magnus Hultdin; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; telomere; telomerase; fluorescence in situ hybridization; flow cytometry; flow-FISH; replication timing; chronic lymphocytic leukemia; immunoglobulin gene; prognosis; Biomedicin; Microbiology; Mikrobiologi; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : The telomeres are specialized structures at the end of the chromosomes composed of the repeated DNA sequence (TTAGGG)n and specific proteins bound to the DNA. The telomeres protect the chromosomes from degradation and end to end fusions. LÄS MER

  2. 2. Genetic characterization of non-Hodgkin lymphomas using in situ hybridization

    Författare :Svetlana Lagercrantz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Myelodysplastic syndrome; non-Hodgkin lymphoma; fluorescencein situ hybridization; LAZ3BCL6 expression; chromosome rearrangements;

    Sammanfattning : Fluorescence in situ hybridization (FISH) has been shown to be a valuable andimportant technique in cytogenetics, as a complement to traditional bandinganalysis. This thesis focus on the characterization of chromosomalrearrangements in two hematological neoplasias, myelodysplastic syndrome(MDS) and non-Hodgkin lymphoma (NHL) using FISH. LÄS MER

  3. 3. Applications of in situ proximity ligation assays for cancer research and diagnostics

    Författare :Liza Löf; Masood Kamali-Moghaddam; Ulf Landegren; J.Paul Robinson; Uppsala universitet; []
    Nyckelord :Cancer; Diagnostics; Research; Prognostics; Method development; Flow cytometry; Drug delivery; Molekylär medicin; Molecular Medicine;

    Sammanfattning : In the field of cancer research and diagnostics it is crucial to have reliable methods for detecting molecules involved in the disease. New and better methods for diagnostics, prognostics and drug delivery therefore remain a permanent aim. LÄS MER

  4. 4. Genotyping RNA and DNA using padlock probes

    Författare :Dan-Oscar Antson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Padlock probe; enzymatic synthesis; PCR; in situ hybridization; RNA-templated DNA ligation; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Novel techniques are needed to investigate the genetic variation revealed in the first draft of the human genome sequence. Padlock probes are recently developed reagents, suitable for detecting single-nucleotide variations of DNA and RNA in situ or in solution. LÄS MER

  5. 5. Biotechnological treatment of chlorophenol-contaminated water

    Författare :Hamid Zilouei; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biotechnology; Bioteknik; kontroll av utsläpp; Miljöteknik; pollution control; Environmental technology; Cell-based biosensor; Fluorescence in situ hybridization; Bacterial community; Two-liquid phase partitioning bioreactor; Photolysis pretreatment; Biomonitoring; Fixed-biofilm reactors; Toxic organic pollutant; Biodegradation;

    Sammanfattning : Widespread presence of toxic and persistent pollutants in the environment, even at low concentrations, causes risks of adverse effects to human health and the ecosystem. Biological methods for treatment of water streams and removal of persistent pollutants are of great interest due to their simplicity, low cost, and mild operational conditions without harmful by-products. LÄS MER