Sökning: "fitness costs"

Visar resultat 1 - 5 av 81 avhandlingar innehållade orden fitness costs.

  1. 1. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution

    Författare :Fredrika Rajer; Linus Sandegren; Pål Jarle Johnsen; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

    Sammanfattning : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. LÄS MER

  3. 2. Removal and Replacement of Ribosomal Proteins : Effects on Bacterial Fitness and Ribosome Function

    Författare :Christina Tobin; Dan I. Andersson; Richard Buckingham; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ribosome; protein synthesis; ribosomal proteins; translation initiation; ribosome biogenesis; fitness costs; compensatory evolution; horizontal gene transfer; Microbiology; Mikrobiologi; Biochemistry; Biokemi; Mikrobiologi; Microbiology;

    Sammanfattning : Protein synthesis is a complex process performed by sophisticated cellular particles known as ribosomes. Although RNA constitutes the major structural and functional component, ribosomes from all kingdoms contain an extensive array of proteins with largely undefined functional roles. LÄS MER

  4. 3. Resistance to Fluoroquinolones in Escherichia coli: Prevention, Genetics and Fitness Costs

    Författare :Linda L. Marcusson; Diarmaid Hughes; Karl Drlica; Uppsala universitet; []
    Nyckelord :Biology; Fluoroquinolone; Escherichia coli; Resistance; Gyrase; Topoisomerase IV; MPC; Fitness compensation; Urinary Tract Infection; Biologi;

    Sammanfattning : Antibiotic-resistant bacteria are increasingly a major healthcare problem but very few new classes of antibiotics have been discovered or launched in recent decades. Approaches to dealing with the problem include learning how bacteria evolve to resistance and improving dosing regimens with current antibiotics so as to reduce the selection of resistant bacteria. LÄS MER

  5. 4. Costs and Tactics in the Evolution of Reproductive Effort

    Författare :Ingemar Jönsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; capital breeding; Falco tinnunculus; body mass; DEE; reproductive effort; reproductive costs; income breeding; Animal ecology; Djurekologi;

    Sammanfattning : This study focuses on various aspects of costs of reproduction and the evolution of energetic breeding tactics. It emphasizes the distinction between demographic costs of reproduction expressed already before current offspring have reached independence (prebreeding costs), and costs expressed only after offspring independence (postbreeding costs). LÄS MER

  7. 5. Mechanisms of Antibiotic Resistance Evolution

    Författare :Michael Knopp; Dan Andersson; Anca Segall; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance evolution; Escherichia coli; Salmonella; porins; fitness; epistasis; strain-specificity; sub-MIC; de novo gene evolution;

    Sammanfattning : The continuing emergence and spread of antibiotic resistant bacteria are a threat to various applications in modern medicine and impose a strong economic burden on health systems. The development of new antibiotics is slow and cannot counterbalance the dissemination of resistant bacteria. LÄS MER