Sökning: "first-degree relatives"

Visar resultat 16 - 20 av 72 avhandlingar innehållade orden first-degree relatives.

  1. 16. Systemic lupus erythematosus : pathogenesis and genetics with special reference to multicase families

    Författare :Gerður Gröndal; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :SLE; autoimmune disorders; IL- 10; apoptosis; genetics; multicase families.;

    Sammanfattning : Systemic lupus erythematosus (SLE) is a prototype for systemic autoimmune disease. The etiology is largely unknown although valuable knowledge has been accomplished through intensive research in this field in recent years. LÄS MER

  3. 17. Population-based studies on familiality and prognosis in patients with monoclonal gammopathies

    Författare :Sigurður Yngvi Kristinsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Monoclonal gammopathies constitute a group of diseases which have in common an overproduction of monoclonal immunoglobulins, M-proteins. Clues to their etiology have been found in studies showing familial aggregation of these diseases. LÄS MER

  4. 18. Headache in Schoolchildren : Epidemiology, Pain Comorbidity and Psychosocial Factors

    Författare :Katarina Laurell; Matti Sillanpää; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Children; Headache; Tension-type headache; Migraine; Prevalence; Incidence; Prognosis; Pain; Psychosocial factors; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : Headache is the most frequently reported pain in children and is associated with missed schooldays, anxiety, depressive symptoms and various physical symptoms. A secular trend of increasing headache prevalence has been suggested. Few studies have focused on tension-type headache among children from the general population. LÄS MER

  5. 19. If I only had a brain : epidemiological studies of Parkinson's disease

    Författare :Adina Leiah Feldman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is an aging-related movement disorder caused by selective degeneration of dopaminergic neurons in the substantia nigra in the midbrain. Onset of PD symptoms, which include tremor, bradykinesia and rigidity (together referred to as parkinsonism), is most common after age 65. LÄS MER

  7. 20. Genetic predisposition for Multiple Myeloma. Identification and functional characterization of risk variants

    Författare :Laura Duran Lozano; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GWAS; multiple myeloma; CRISPR Cas9; cancer genetics; functional characterization; Germline variants;

    Sammanfattning : Multiple myeloma (MM) is a blood malignancy originating from plasma cells. First-degree relatives of patients with MM have two- to four-fold higher risk of MM. However, the molecular basis remains largely unknown. This Ph. LÄS MER