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Visar resultat 1 - 5 av 72 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Lifestyle intervention in first-degree relatives of patients with type 2 diabetes

   Författare :Hilde Kristin Brekke; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : Type 2 diabetes is increasing worldwide, mainly due to unfavorable changes in diet and physical activity. Prevention strategies to slow this development are urgently needed. First-degree relatives of type 2 diabetic patients (FDR) have an increased risk of developing the disease. LÄS MER

3. 2. Mortality and co-morbidity among patients with hemochromatosis and their first-degree relatives

   Författare :Maria Elmberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Genetic Hemochromatosis; cohort study; health- and census registers; mortality; morbidity; cancer; ischemic heart disese; arthropathy; joint replacement surgery;

   Sammanfattning : Genetic hemochromatosis (GH) is an autosomal recessive disease caused by a C282Y mutation in the HFEgene, and is characterized by excess iron accumulation in multiple organs. Classical manifestations of GH include liver cirrhosis, liver cancer, diabetes mellitus, cardiomyopathy, and arthritis. LÄS MER

4. 3. Early perturbations in lipid metabolism in insulin resistance

   Författare :Else Hellebö Johanson; Göteborgs universitet; []
   Nyckelord :insulin resistance; nateglinide; peak VO2; postprandial; relatives; triglyceride-rich lipoproteins; visceral fat; VLDL;

   Sammanfattning : Subjects with the Metabolic Syndrome with or without type 2 diabetes are at excess risk for developing cardiovascular disease. The mechanisms are still not completely understood. Resistance to insulin-stimulated glucose uptake is associated with several metabolic and hemostatic risk factors for cardiovascular disease. LÄS MER

5. 4. Gene expression in human skeletal muscle : effects of activity, fibre type and inheritance for diabetes

   Författare :Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle; first-degree relatives; type 2 diabetes; spinal cord injury; exercise; AMPK; PPAR; PGC-1;

   Sammanfattning : One fundamental underlying risk factor for the development of non-insulin dependent (type 2) diabetes mellitus is insulin resistance, which 80-90% of all type 2 diabetic patients suffer from. Risk factors for insulin resistance are for example obesity, surgery, severe illness, spinal cord injury, and pregnancy. LÄS MER

7. 5. Insulin signaling and glucose transport in insulin resistant human skeletal muscle

   Författare :Håkan K R Karlsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle; insulin resistance; type 2 diabetes; glucose transport; insulin signaling; first-degree relatives; AS160; SelS; rosiglitazone treatment;

   Sammanfattning : Insulin resistance in skeletal muscle is a hallmark feature of Type 2 diabetes mellitus. The overall aim of this thesis was to investigate downstream intermediates in the insulin signaling pathway in an attempt to characterize the molecular mechanism of skeletal muscle insulin resistance in Type 2 diabetes. LÄS MER