Sökning: "fine-tuned substrate specificity"

Hittade 5 avhandlingar innehållade orden fine-tuned substrate specificity.

1. 1. galactmannan degradation by fungi and gut bacteria : structural enzymology and fine -tuned substrate specifcity

   Författare :Sumitha Krishnaswamyreddy; Biokemi och Strukturbiologi; []
   Nyckelord :fine-tuned substrate specificity; β-mannanase; β-mannosidases; synergy; α-galactosidases; mannan converison in gut; transglycosylation; polysaccharide utilisation locus; phylogenetic analysis; MALDI-TOF MS;

   Sammanfattning : AbstractThe degradation of plant based β-mannan polysaccharides represents one of the many challenges efficiently tackled by microorganisms living in different habitats. In this thesis, glycoside hydrolases (GHs) involved in mannan degradation from two different organisms, Aspergillus nidulans (paper I and II) and Bacteroides ovatus (paper III and IV) were studied. LÄS MER

3. 2. Type III secretion- the various functions of the translocon operon in bacterial pathogenesis

   Författare :Jeanette E Bröms; Åke Forsberg; Michael Koomey; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Yersinia; Pseudomonas aeruginosa; type III secretion; chaperone; translocation; regulation; lcrGVHyopBD; pcrGVHpopBD; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

   Sammanfattning : In order to establish colonisation of a human host, pathogenic Yersinia use a type III protein secretion system to directly intoxicate host immune cells. Activation of this system requires target cell contact and is a highly regulated process. LÄS MER

4. 3. Cellular Control and Physiological Importance of Vascular Lignification

   Författare :Leonard Blaschek; Edouard Pesquet; Richard Sibout; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; växtfysiologi; Plant Physiology;

   Sammanfattning : Lignin is indispensable for vascular plants. It allows their cells to coalesce into gravity-defying giants, hardens them to withstand pressures and predators, and waterproofs them to allow the flow of water only where it is advantageous. LÄS MER

5. 4. β-Mannan degradation by gut bacteria - Characterization of β-mannanases from families GH5 and GH26

   Författare :Evelina Kulcinskaja; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glycoside hydrolases; gut microflora; mannan; enzymes; GH26; GH5; β-mannanase;

   Sammanfattning : The human gut flora is important for our well-being. The gut bacteria are able to degrade and metabolize complex carbohydrates. Examples of such carbohydrates are β-mannans. β-Mannans consist of a backbone of β-1,4-linked mannose units and are present in e. LÄS MER

7. 5. Regulated Proteolysis: The Secrets of Lon : Cellular Roles and Stress-dependent Regulation of the Lon Protease

   Författare :Matthias J. Fink; Kristina Jonas; Axel Mogk; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Lon protease; regulated proteolysis; allosteric regulation; Caulobacter crescentus; stress responses; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : Proteolysis is crucial in cells to maintain a functional proteome. It is required for removal of damaged and unfolded proteins during protein quality control, and serves as a mechanism to regulate protein levels through regulated proteolysis. LÄS MER