Sökning: "filgrastim."

Hittade 5 avhandlingar innehållade ordet filgrastim..

  1. 1. Kostmann syndrome : a clinical and pathophysiological study

    Författare :Göran Carlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Kostmann syndrome; severe congenital neutropenia; autosomal recessive; periodontitis; antibacterial peptides; LL-3 7; apoptosis; Bcl-2; granulocyte colony-stimulating factor; glycosylation; lenograstim; filgrastim.;

    Sammanfattning : Kostmann syndrome or severe congenital neutropenia (SCN) is a rare disease, usually diagnosed during the first months of life, characterized by extremely low levels of neutrophils in the peripheral blood, a maturational arrest of the myelopoiesis in the bone marrow and severe bacterial infections. The purpose of this project was to improve the understanding of the clinical course and the pathophysiology of autosomal recessive SCN. LÄS MER

  3. 2. Potential Hazards for Haematopoietic Stem Cell Donors

    Författare :Simon Pahnke; Hans Hägglund; Gunnar Larfors; Nina Worel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell donor; stem cell transplantation; cancer; haematology; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The aim of this thesis has been to increase our knowledge about the allogeneic stem cell donation procedure and the associated risks for stem cell donors.  In a first study (paper I), we described the donation procedure and short-term side effects of 1957 donors included in the Nordic Register of Haematopoietic Stem Cell Donors. LÄS MER

  4. 3. Engineering Yeast for the Production of Biologicals

    Författare :Veronica Gast; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biopharmaceuticals; genome-scale models.; kinase Gcn2; Recombinant protein production; proteases; Saccharomyces cerevisiae; biologicals;

    Sammanfattning : The market for biopharmaceutical proteins, or biologicals, has been expanding rapidly over the last decades and its value was estimated in 2020 to exceed 300 billion US dollars. Efficient cell factories that produce the biologicals fulfill an essential role within this industry. LÄS MER

  5. 4. Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients

    Författare :Eva Ösby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aggressive; non-Hodgkin s lymphoma; elderly; CHOP; mitoxantrone; etoposide; G-CSF; response evaluation; longevity;

    Sammanfattning : The age-adjusted incidence rate of non-Hodgkin´s lymphoma (NHL), in particular diffuse large B cell lymphoma, has increased continuously during several decades. Patients with aggressive NHL are potentially curable but the 5-year overall survival (OS) is still less than 50% in the whole group. LÄS MER

  7. 5. Esophageal cancer : evaluation of some new strategies

    Författare :Dag Stockeld; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Esophageal; cancer; fine needle; cytology; prognosis; immunohistochemistry; nutrition; PEG;

    Sammanfattning : Objective: To study and to evaluate new strategies regarding the diagnosis, treatment and nutrition of esophageal cancer patients. Methods: A background retrospective analysis of the files of all 1284 esophageal cancer patients in Stockholm County 1978 - 1995 was performed and followed by a multicenter study of the development and evaluation of a cisplatinum based chemoradiation protocol for the treatment of nonmetastatic squamous cell carcinoma of the esophagus. LÄS MER