Sökning: "fibroblast growth factor signaling"

Visar resultat 11 - 15 av 41 avhandlingar innehållade orden fibroblast growth factor signaling.

  1. 11. Syndecan - Regulation and Function of its Glycosaminoglycan Chains

    Författare :Anna S. Eriksson; Dorothe Spillmann; Catherine Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulfate; chondroitin sulfate; integrin; cell motility; fibroblast growth factor signaling; pharyngeal cartilage; biosynthesis regulation; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The cell surface is an active area where extracellular molecules meet their receptors and affect the cellular fate by inducing for example cell proliferation and adhesion. Syndecans and integrins are two transmembrane molecules that have been suggested to fine-tune these activities, possibly in cooperation. Syndecans are proteoglycans, i.e. LÄS MER

  3. 12. Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea

    Författare :Katherine B Szarama; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cells in the mammalian hearing organ, the cochlea, develop a specialized patterning and cellular architecture necessary for hearing function. Cytoskeletal components, such as actin and microtubules, maintain the material and mechanical properties of these cells. LÄS MER

  4. 13. N-Unsubstituted Glucosamine Residues in Heparan Sulfate and Their Potential Relation to Alzheimer's Disease

    Författare :Camilla Westling; Ulf Lindahl; Svein Olav Kolset; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; heparan sulfate; N-unsubstituted glucosamine; Alzheimer s disease; amyloid beta peptide; amyloidosis; 10E4 antibody; fibroblast growth factor 2; Biokemi; Biochemistry; Biokemi;

    Sammanfattning : Heparan sulfate (HS) is a linear polysaccharide, located on the surface and in the extracellular matrix of most cells, that regulates functions of numerous proteins. HS-protein interaction is mainly mediated by sulfate groups found in N-sulfated (NS) regions of the HS, but may also involve rare HS substituents such as N-unsubstituted glucosamine (GlcNH2) residues. LÄS MER

  5. 14. Molecular complexities of patched signaling in cancer development

    Författare :Fahimeh Rahnama; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Basal Cell Carcinoma; Patched; Sonic Hedgehog; Desert Hedgehog; Splice variants; Skin;

    Sammanfattning : Basal Cell Cancer (BCC) is the most common cancer in the Western world. Although BCCs hardly ever metastasize, invasive growth may cause considerable local tissue destruction. BCCs mainly occur as sporadic tumors but can also be found in a hereditary form in the Nevoid Basal Cell Carcinoma Syndrome (NBCCS). LÄS MER

  7. 15. FGF signaling in specification of hESC-derived definitive endoderm

    Författare :Jacqueline Ameri; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Diabetes affects around 200 million people worldwide. Curing diabetes would require the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. LÄS MER