Sökning: "fibroblast growth factor 23"

Visar resultat 6 - 10 av 21 avhandlingar innehållade orden fibroblast growth factor 23.

1. 6. Heparan Sulfate Regulation of Fibroblast Growth Factor (FGF) Receptor-1 Signal Transduction

   Författare :Lars Lundin; Lena Claesson-Welsh; Marco Presta; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; FGF; FGFR; dimerisation; signal transduction; heparan sulfate; proteoglycan; heparin; VEGF; embryonal stem cell; endothelial cell; differentiation; Patologi; Pathology; Patologi;

   Sammanfattning : Fibroblast growth factors (FGFs) constitute a family (currently FGF-1 to FGF-23) of polypeptides that are essential in embryonal development and adult physiology, in animals from nematodes to humans. FGFs bind to four receptor tyrosine kinases, denoted FGFR-1 to FGFR-4. LÄS MER

3. 7. Body composition, arteriosclerosis and exercise training in patients with chronic kidney disease

   Författare :Yunan Zhou; Njurmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chronic kidney disease CKD ; exercise training; muscle mass; Sarcopenia; arteriosclerosis; Abdominal aortic calcification AAC ; myostatin; Lipids; lipoproteins; Fibroblast growth factor 23; fetuin-A; Interleukin 6;

   Sammanfattning : .... LÄS MER

4. 8. Stem cell transplantation in multiple myeloma : clinical aspects and experimental gene transfer studies

   Författare :Bo Björkstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :multiple myeloma; bone marrow transplantation; allogeneic; autologous; prognostic factors; hemato-poietic stem eells; gene therapy; gene transfer; retrovirus; basic fibroblast growth factor;

   Sammanfattning : Multiple myeloma (MM) is a hematological malignant disease considered essentially incurable despite its sensitivity to cytotoxic chemotherapeutic drugs and radiation. High-dose chemo/radiotherapy with allogeneic- or autologous hematopoietic stem cell transplantation (tx) can induce a disease-free state and may prolong survival and offer an improved quality of life to MM patients. LÄS MER

5. 9. Renal Klotho in mineral metabolism

   Författare :Risul Amin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Calcium and phosphorous are critical elements in a number of physiological processes, including maintenance of bone structure, cell signaling and energy metabolism. Their endocrine regulation is tightly controlled through a number of feedback mechanisms involving parathyroid hormone (PTH), vitamin D and the recently discovered fibroblast growth factor 23 (FGF23). LÄS MER

7. 10. Studies on bone and mineral disorders in CKD : determinants and survival implications

   Författare :Ting Jia; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Disruptions in mineral metabolism occur already at an early stage of chronic kidney disease (CKD) and may eventually lead to a complex of CKD - mineral and bone disorders (CKD-MBD) characterized by alterations of the mass, turnover rate, mineralization and strength of bones, and high risk of vascular calcification, fractures and other complications resulting in worse survival. The aim of this thesis was to increase the understanding of some aspects of CKD-MBD with special emphasis on clinical and laboratory determinants and implications for clinical outcome. LÄS MER