Sökning: "fibrinogen gamma"

Hittade 5 avhandlingar innehållade orden fibrinogen gamma.

  1. 1. Experimental studies on thrombin inhibition in acute- and chronic models of vessel wall injury

    Författare :Fredrik Scherstén; Göteborgs universitet; []
    Nyckelord :animal model; antithrombin; fibrinogen; histomorphology; melagatran; percutaneous coronary intervention; platelets; restenosis; stent; thrombin inhibition; thrombosis;

    Sammanfattning : Background: The number of percutaneous coronary interventions (PCI) performed worldwide has increased dramatically during the last decade. Complication rates have decreased over time, however the restenosis phenomenon remains an unsolved issue. Thrombin is the key regulator in the pro-coagulant state following PCI. LÄS MER

  3. 2. Fibrinogen and susceptibility to myocardial infarction : role of gene-gene and gene-environment interactions

    Författare :Maria Nastase Mannila; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherothrombosis; epistasis; fibrinogen; fibrinogen gamma; fibrin clot structure; haplotypes; myocardial infarction; pleiotropy; SNPs;

    Sammanfattning : Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in plasma at concentrations normally ranging between 2-4 g/L. The fibrinogen molecule consists of two sets of three non-identical polypeptide chains, which are encoded by the fibrinogen gamma (FGG), fibrinogen alpha (FGA) and fibrinogen beta (FGB) genes clustered on chromosome 4. LÄS MER

  4. 3. Null Ellipsometry and Protein Adsorption to Model Biomaterials

    Författare :Johan Benesch; Thomas Arnebrant; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : When implants are inserted into the human body cascades of events become started that will determine the outcome of wound healing and ultimately the success of the implantation. The events start with the adsorption of small molecules, and proteins that may be activated (enzymes) or are able to activate cells of the immune defense and the healing process. LÄS MER

  5. 4. Metal release from stainless steel and CoCrMo alloys in protein-rich environments – effects of protein aggregation, friction, and irradiation

    Författare :Zheng Wei; Yolanda Hedberg; Inger Odnevall Wallinder; Daniel Klint; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Metal release; stainless steel; CoCrMo; protein aggregation; friction; irradiation; Vroman effect; Kemi; Chemistry;

    Sammanfattning : Highly corrosion-resistant alloys are used in sensitive environments such as the human body and food environments. However, even tiny amounts of released metals from these surfaces could potentially cause adverse effects. It is hence important to study the biointerface between corrosion-resistant alloys and protein-rich environments. LÄS MER

  7. 5. Free oscillation rheometry in the assessment of platelet quality

    Författare :Nahreen Tynngård; Gösta Berlin; Tomas Lindahl; James AuBuchon; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coagulation; elasticity; platelets; rheology; transfusion; Transfusion medicine; Transfusionsmedicin;

    Sammanfattning : Platelets play an important role in the haemostatic process in order to seal damaged blood vessels. The platelets form a platelet plug at the damaged area and prevent blood loss. Once the damage to the vessel wall has been covered, the platelets retract the coagulum, to allow the blood to flow freely in the vessel. LÄS MER