Sökning: "fibrin gel porosity"

Hittade 4 avhandlingar innehållade orden fibrin gel porosity.

  1. 1. Studies on fibrin gel structure

    Författare :Kamaran T Fatah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Fibrinogen; fibrin gel structure; plasma; thrombin; fibrinolysis; fibrin gel; zinc ion; plasminogen; crosslinking; acetylsalicylic acid; atherosclerosis; coronary heart disease;

    Sammanfattning : Fibrin gel formation is the final result of interaction between multiple plasma proteins; as a result of activation, fibrinogen is converted to fibrin and crosslinking of fibrin occurs by activated factor XIII, which stabilises the formed clot. Fibrin gel networks were studied in purified fibrinogen systems and in plasma samples from patients with cardiovascular complications and healthy individuals, using light-scattering, turbidity, liquid permeation and confocal 3D microscopy techniques. LÄS MER

  3. 2. Determination of the overall haemostasis potential and fibrin gel permeability : method development and application in research and in clinical materials

    Författare :Aleksandra Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Global haemostatic assays; overall haemostasis potential; hypercoagulation; hypocoagulation; thrombophilia; haemophilia; fibrin gel porosity; LMMH therapy; acetylsalicylic acid therapy;

    Sammanfattning : We have previously developed a laboratory method that may screen the Overall Haemostasis Potential (OHP) in plasma based on spectophotometric measurement of an area under the fibrin aggregation curve in citrated plasma samples to which tiny amounts of exogenous thrombin and tissue-plasminogen activator (t-PA) are added. When the fibrin aggregation curve is created, the fibrinogen originally present in plasma is gradually converted to fibrin by the generated thrombin. LÄS MER

  4. 3. Diabetic skin microangiopathy : studies on pathogenesis and treatment

    Författare :Majid Kalani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Diabetes mellitus; chronic foot ulcers; skin microcirculation; peripheral arterial occlusive disease; blood coagulation; fibrinolysis; fibrin gel structure; low molecular weight heparin; dalteparin.;

    Sammanfattning : Background: Most of late diabetic complications have their basis in a disturbed microcirculation, i.e. diabetic microangiopathy. LÄS MER

  5. 4. Fibrinogen and susceptibility to myocardial infarction : role of gene-gene and gene-environment interactions

    Författare :Maria Nastase Mannila; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherothrombosis; epistasis; fibrinogen; fibrinogen gamma; fibrin clot structure; haplotypes; myocardial infarction; pleiotropy; SNPs;

    Sammanfattning : Fibrinogen, the precursor of fibrin, is a glycoprotein synthesized in the liver and maintained in plasma at concentrations normally ranging between 2-4 g/L. The fibrinogen molecule consists of two sets of three non-identical polypeptide chains, which are encoded by the fibrinogen gamma (FGG), fibrinogen alpha (FGA) and fibrinogen beta (FGB) genes clustered on chromosome 4. LÄS MER