Sökning: "fatty acid amide hydrolase"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden fatty acid amide hydrolase.

  1. 1. Fatty acid amide hydrolase - A target for anti-inflammatory therapies?

    Detta är en avhandling från Umeå : Farmakologi och klinisk neurovetenskap

    Författare :Sandra Holt; Umeå universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; FAAH; anandamide; endocannabinoid; pH; inflammation; NSAID; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anti-inflammatory drugs are a widely used class of therapeutic agents, but the use of non-steroidal anti-inflammatory drugs (NSAID) is hampered by their gastrointestinal side-effects. Recent reports that cyclooxygenase-2 inhibitors may cause cardiovascular events underline the importance of identifying new therapeutic strategies for the treatment of inflammation. LÄS MER

  2. 2. Endocannabinoid metabolism the impact of inflammatory factors and pharmacological inhibitors

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Jessica Karlsson; Umeå universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; endocannabinoid; anandamide; 2-AG; fatty acid amide hydrolase; cyclooxygenase-2; prostate cancer; catabolism; inflammation; inflammatory factors;

    Sammanfattning : The endocannabinoid (eCB) system is an endogenous signaling system consisting of ligands (referred to as endocannabinoids, eCBs), receptors and metabolic enzymes. The eCB system is involved in homeostatic control of a variety of biological functions such as neuronal signaling, mood, appetite and pathological conditions such as pain, inflammation and tumour progression. LÄS MER

  3. 3. The cellular processing of the endocannabinoid anandamide and its pharmacological manipulation

    Detta är en avhandling från Umeå : Farmakologi och klinisk neurovetenskap

    Författare :Lina Thors; Umeå universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocannabinoid; anandamide; cellular processing; pain; flavonoids; fatty acid amide hydrolase; MEDICINE Physiology and pharmacology Pharmacological research Pharmacology; MEDICIN Fysiologi och farmakologi Farmakologisk forskning Farmakologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) exert most of their actions by binding to cannabinoid receptors. The effects of the endocannabinoids are short-lived due to rapid cellular accumulation and metabolism, for AEA, primarily by the enzymes fatty acid amide hydrolase (FAAH). LÄS MER

  4. 4. Pharmacology of Palmitoylethanolamide and Related Compounds

    Detta är en avhandling från Umeå : Farmakologi och klinisk neurovetenskap

    Författare :Kent-Olov Jonsson; Umeå universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; anandamide; cannabinoid; FAAH; palmitoylethanolamide; palmitoylisopropylamide; inflammation; mast cells; Farmakologi; MEDICINE Physiology and pharmacology Pharmacological research; MEDICIN Fysiologi och farmakologi Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anandamide (AEA) is an endogenous fatty acid which activates the same cannabinoid receptors as ∆9-tetrahydrocannabinol, the psychoactive substance in marijuana. In vivo, anandamide exerts a number of actions including effects upon pain and inflammation. LÄS MER

  5. 5. Bioactive Lipids in Nociception

    Detta är en avhandling från Clinical Chemistry and Pharmacology, Dept of Laboratory Medicine

    Författare :Anna Ermund; Lund University.; Lunds universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; Anandamide; AM404; 2-Arachidonoylglycerol; Acetaminophen; Cyclooxygenase; Nocicieption; TRPV1;

    Sammanfattning : This thesis focuses on bioactive lipids as (1) metabolites of the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty acid conjugation of p-aminophenol, a known acetaminophen metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. LÄS MER