Sökning: "familial multiple myeloma"

Hittade 5 avhandlingar innehållade orden familial multiple myeloma.

  1. 1. Genetic Predisposition to Sporadic and Familial Multiple Myeloma

    Författare :Britt-Marie Halvarsson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; genetics; inherited predisposition; familial multiple myeloma; GWAS; polygenic risk score;

    Sammanfattning : Multiple Myeloma (MM) is the second most common hematological malignancy. It is defined by an uncontrolled growth of plasma cells, usually in the bone marrow. Clinically it is complicated by hypercalcemia, renal failure, anaemia, and bone pain. LÄS MER

  3. 2. Epidemiological studies on multiple myeloma

    Författare :Mikael Eriksson; Lennart Hardell; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; multiple myeloma; epidemiology; farming; domestic animals; phenoxyacetic adds; DDT; rheumatoid arthritis; familial factors;

    Sammanfattning : Multiple myeloma is a painful and uncurable malignant disease with an increasing incidence and mortality in several countries, e.g., Sweden. Some factors are suspected to be of aetiological significance, such as ionising radiation and chronic antigenic stimulation in certain inflammatory diseases. LÄS MER

  4. 3. Genetic polymorphism and natural killer cell activity in multiple myeloma

    Författare :Chengyun Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple Myeloma (MM) is a B cell malignancy characterised by an accumulation of clonal neoplastic plasma cells in bone marrow. Its aetiology remains unknown. Remarkable racial differences in the incidence of MM and occurrence of familial MM suggest that genetic factors may play a role in the development of MM. LÄS MER

  5. 4. Waldenstrom's macroglobulinemia : population based studies of familial aggregation and prognostic factors

    Författare :Lena Brandefors; Beatrice S. Melin; Ola Landgren; Umeå universitet; []
    Nyckelord :Waldenstrom’s macroglobulinemia; lymphoplasmacytic lymphoma; monoclonal gammopathy of undetermined significance; Swedish Lymphoma Registry; incidence; overall survival; prognostic factors; familial Waldenstrom’s macroglobulinemia; hyperphosphorylated paratarg 7;

    Sammanfattning : BackgroundWaldenstrom’s macroglobulinemia (WM) is a rare lymphoproliferative disorder with a world-wide incidence of 3-4 patients per million persons per year. In Sweden, the incidence was about three times higher, and approximately 100 patients per year are reported to the Swedish Lymphoma Registry (SLR). LÄS MER

  7. 5. Population-based studies on familiality and prognosis in patients with monoclonal gammopathies

    Författare :Sigurður Yngvi Kristinsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Monoclonal gammopathies constitute a group of diseases which have in common an overproduction of monoclonal immunoglobulins, M-proteins. Clues to their etiology have been found in studies showing familial aggregation of these diseases. LÄS MER