Sökning: "facs"

Visar resultat 11 - 15 av 66 avhandlingar innehållade ordet facs.

  1. 11. Tagging systems for sequencing large cohorts

    Författare :Mårten Neiman; Afshin Ahmadian; Peter Savolainen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; next generation sequencing; genotyping; massive parallel sequencing; 454; Pyrosequencing; amplicon sequencing; enrichment; DNA barcodes; Genetics; Genetik;

    Sammanfattning : Advances in sequencing technologies constantly improves the throughput andaccuracy of sequencing instruments. Together with this development comes newdemands and opportunities to fully take advantage of the massive amounts of dataproduced within a sequence run. LÄS MER

  3. 12. Gene regulation in normal and malignant B-lineage cells

    Författare :Lucía Peña Pérez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : B-cells are the central players of humoral immunity. It is known that their development is orchestrated by a small group of transcription factors including the E-proteins and the FOXO proteins, yet this process is far from completely understood. LÄS MER

  4. 13. Staphylococcal surface display and its applications in bioscience

    Författare :Patrik Samuelson; KTH; []
    Nyckelord :;

    Sammanfattning : Display of heterologous proteins on the surface ofmicroorganisms, enabled by means of recombinant DNA technology,has become an increasingly used strategy in variousapplications in microbiology, biotechnology and vaccinology.This thesis presents two bacterial systems, designed forsurface display of chimeric proteins on the food-gradestaphylococcal speciesStaphylococcus xylosusandStaphylococcus carnosus, respectively. LÄS MER

  5. 14. Preservation of male fertility in childhood acute leukemia : an experimental study addressing novel strategies and putative risks

    Författare :Mi Hou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Although treatment of cancer in young boys with cytotoxic agents has long been known to cause infertility in the survivors, the mechanisms underlying drug-induced damage to the immature testis remain unclear. A number of clinical issues associated with transplantation of testicular germ cells or tissues also require clarification. LÄS MER

  7. 15. Genomic and Molecular Aspects of Mature Human B Cells

    Författare :Carl-Magnus Högerkorp; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Human; B-cell; Germinal center; Centroblast; serology; Immunology; onkologi; cancer; Cytologi; cancerology; oncology; Microarray; Cytology; Mantel cell lymphoma; Immunologi; serologi; Centrocyte;

    Sammanfattning : This thesis covers aspects of the mature human B cell and its different guises on its way to become a fully differentiated antibody forming plasma cell (AFC), the key player in the humoral immune system. The understanding of the complex molecular mechanisms taking place in the B cell, as it first encounters antigen, enters the germinal center (GC) reaction, giving rise to memory cells and plasma cells, is not only of importance for the curious scientist, but will also benefit the understanding of B cells in disease. LÄS MER