Sökning: "extrinsic and intrinsic loss"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden extrinsic and intrinsic loss.
1. Intrinsic and extrinsic factors controlling the differentiation of human midbrain progenitor cells
Sammanfattning : Parkinson's disease (PD) is a common neurodegenerative disorder characterized by motor deficits. Levodopa treatment provides marked symptomatic relief. However, within 5-10 years after the start of Levodopa treatment, most PD patients display a gradual loss of drug efficacy. LÄS MER
2. Novel Insights into Haematopoietic Stem Cell Regulation and Function
Sammanfattning : The haematopoietic stem cell (HSC) is a somatic stem cell essential for life long haematopoiesis; HSCs have the capability to differentiate into all mature types of blood cells and can also undergo self-renewal to maintain their own numbers. They also have the potential to reconstitute a complete haematopoietic system following HSC transplantation, also known as bone marrow transplantation, which is used to treat many haematopoietic disorders. LÄS MER
3. Vibration-induced muscle injury in the hand - experimental and clinical studies
Sammanfattning : Exposure to vibration is known to cause vasospastic white fingers and/or sensorineural symtoms such as numbness and tingling in fingers and/or musculoskeletal disorders such as reduction in muscle force, fatigue and reduced endurance. Classifications for the vasospastic and sensorineural symptoms are established. LÄS MER
4. On the origin of B cells. Elucidating the Role of Tyrosine Kinase Receptors in B Cell Development
Sammanfattning : B cells are essential cells that are part of the adaptive immune system with the capacity to produce antibodies against exogenous antigens. These cells are produced through a process called hematopoiesis, tightly regulated by extrinsic and intrinsic factors. LÄS MER
5. Regulation of the germinal center response by T follicular helper cells and type I interferons
Sammanfattning : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. LÄS MER