Sökning: "extravasation"

Visar resultat 1 - 5 av 56 avhandlingar innehållade ordet extravasation.

  1. 1. Nitric oxide and extravasation in endotoxaemia : an experimental study

    Författare :Kerstin Metcalf; Mikael Bodelsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Background: Despite advances in intensive care the mortality of patients in septic shock is still high. In early stages the condition is characterised by circulatory failure that is a consequence of myocardial depression, vasodilatation with decreased sensitivity to catecholamine stimulation and increased loss of protein and fluid from the circulation. LÄS MER

  3. 2. Expression, recognition and usage of laminin-8 (a4b1g1, Lm-411) by monocytes and neutrophils

    Författare :Zenebech Wondimu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Basement membrane; laminins; myeloid cells; extravasation; migration.;

    Sammanfattning : Laminins (LNs) are a family of large alphabetagamma heterotrimeric glycoproteins found in all basement membranes (BMs). They are expressed in a tissue- and developmental stagespecific manner and implicated in vital cellular functions, including cell adhesion, migration and signaling. LÄS MER

  4. 3. Mechanisms for leukocyte-mediated adjustment of endothelial barrier function

    Författare :Narinder Gautam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Inflammation; leukocyte extravasation; endothelial cells; vascular permeability; plasma leakage integrin signaling; heparin binding protein; contact phase; bradykinin.;

    Sammanfattning : Extravasation of polymorphonuclear leukocytes (PMN) and associated plasma exsudation are key events in the inflammatory process. The mechanism by which activated PMN may induce increased vascular permeability for macromolecules is not fully understood but crucially dependent on an intact leukocytic beta2 integrin (CD11/CD18) adhesion receptor function. LÄS MER

  5. 4. Interaction of human blood platelets, lymphocytes and monocytes with vascular laminin isoforms

    Författare :Gezahegn Gorfu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vascular laminin isoforms; extracellular matrix; integrins; cell adhesion; cell migration; high endothelial venules; lymphocytes; monocytes; platelets; leukocyte extravasation;

    Sammanfattning : Inflammatory and immune responses play a fundamental role in both health and disease, and leukocytes are important actors in these processes. Migration of the leukocytes to sites of injury or inflammation is a crucial component of innate and adaptive immunity. It is currently accepted that leukocyte extravasation is a multistep process. LÄS MER

  7. 5. Functions of integrin receptors in extravascular neutrophil migration and respiratory burst

    Författare :Joachim Werr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adhesion molecules; leukocyte migration; neutrophils; chemotaxis; integrins; respiratory burst; leukocyte extravasation; extracellular matrix; intravital microscopy; acute inflammation;

    Sammanfattning : Leukocytes circulate in the vasculature, but, must leave the blood stream and migrate through the surrounding tissue to exert their protective functions in inflammation. Numerous studies have revealed that intravascular leukocyte-endothelial cell interactions involve functions of adhesion molecules belonging to the selectin and integrin receptor families. LÄS MER