Sökning: "extracellular retention"
Visar resultat 1 - 5 av 47 avhandlingar innehållade orden extracellular retention.
1. Extracellular Matrix Based Materials for Tissue Engineering
Sammanfattning : The extracellular matrix is (ECM) is a network of large, structural proteins and polysaccharides, important for cellular behavior, tissue development and maintenance. Present thesis describes work exploring ECM as scaffolds for tissue engineering by manipulating cells cultured in vitro or by influencing ECM expression in vivo. LÄS MER
2. Role of extracellular retention of platelet-derived growth factor-B. Functions in development and disease
Sammanfattning : During development, the cell secretes growth and differentiation factors (GDFs) to the surrounding microenvironment. These factors are often key regulators of organogenesis and embryogenesis. Several GDFs carry sequences that mediate specific interaction with molecules of the extracellular matrix (ECM) that surrounds the cell. LÄS MER
3. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor
Sammanfattning : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. LÄS MER
4. Sorting and processing of neutrophil granule proteins
Sammanfattning : The neutrophil granulocytes have a critical role in innate immunity in particular through phagocytosis of microorganisms. Their cytoplasmic granule subsets store digestive enzymes and antibiotic proteins that are released during this event. LÄS MER
5. Extracellular factors for preservation and delivery of stromal cells
Sammanfattning : Modulating the immune response after a myocardial infarction seems like an appropriate strategy for reducing myocardial fibrosis. Mesenchymal Stromal Cells are immunomodulatory and have thus gained interest, but have so far not achieved the desired clinical outcomes. LÄS MER