Sökning: "extracellular DOC"
Hittade 5 avhandlingar innehållade orden extracellular DOC.
1. Microphysiometry in the evaluation of cytotoxic drugs with special emphasis on the novel cyanoguanidine CHS 828
Sammanfattning : This thesis describes the use of a new technology, the Cytosensor® microphysiometer, in the in vitro evaluation of cytotoxic drugs, using the lymphoma cell line U-937 GTB and primary cultures of tumour cells from patients as model systems. The method was specifically applied to study the metabolic effects of the novel cyanoguanidine N-(6-(4-chlorophenoxy)hexyl)-N’-cyano-N’’-4-pyridylguanidine, CHS 828, currently in phase I/II clinical trials. LÄS MER
2. Organic carbon dynamics in the Baltic Sea : A modelling perspective
Sammanfattning : Coastal seas constitute a link between land and the open ocean, and therefore play an important role in the global carbon cycle. Large amounts of carbon, of both terrestrial and marine origin, transit and are transformed in these waters, which belong to the more productive areas of the oceans. LÄS MER
3. Interactions between Bacteria and Fungi on Aquatic Detritus – Causes and Consequences
Sammanfattning : Bacteria and fungi dominate the decomposition of aquatic plants, a major process in the carbon and nutrient cycling in many aquatic systems. Although phylogenetically distant, bacteria and fungi often live in close proximity with each other. Since these microorganisms also have similar ecological functions, interactions have developed between them. LÄS MER
4. Utilization of terrestrially derived dissolved organic nitrogen by aquatic bacteria
Sammanfattning : I investigated the bacterial utilization of terrestrially derived dissolved organic nitrogen (DON) in aquatic ecosystems, and assessed the potential role of river-born DON in marine eutrophication. To determine the bioavailability of DON, I developed a bioassay employing N-limited bacterial regrowth cultures, which were calibrated with additions of inorganic nitrogen. LÄS MER
5. Chemical, pharmacokinetic and biological aspects of platinum-based drugs
Sammanfattning : The use of cisplatin for the treatment of metastatic testicular cancer is a medical historical landmark given that, for the first time, patients could be cured with drug therapy. A third generation platinum-based drug, oxaliplatin, has been registered for use in the treatment of colorectal cancer. LÄS MER