Sökning: "extracellular DNA"
Visar resultat 6 - 10 av 168 avhandlingar innehållade orden extracellular DNA.
6. Isolation Strategies and Proteomic Characterization of Extracellular Vesicles
Sammanfattning : “Extracellular vesicles” is the collective term used to describe vesicular entities that are released from cells into the extracellular environment. These vesicles are composed of a delineating lipid membrane and its cargo which can comprise of bioactive molecules such as lipids, RNA, DNA and proteins which can be shuttled between cells and thus function as a means of cell-to-cell communication. LÄS MER
7. About hyaluronan in the hypertrophic heart : studies on coordinated regulation of extracellular matrix signalling
Sammanfattning : Background. Myocardial hypertrophy is a risk factor for cardiovascular morbidity and mortality. Independent of underlying disease, the cardiac muscle strives in different ways to compensate for an increased workload. This remodelling of the heart includes changes in the extracellular matrix which will affect systolic and diastolic cardiac function. LÄS MER
8. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes
Sammanfattning : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. LÄS MER
9. Exploring human variations by droplet barcoding
Sammanfattning : Biological variations are being explored at ever-increasing rates through the rapid advancement of analytical techniques. Techniques like massively parallel sequencing empower scientists to accurately differentiate individuals’ genetic compositions, cellular functionalities, and healthy tissue from diseased. LÄS MER
10. Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content
Sammanfattning : ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene activity not caused by changes in DNA sequences). LÄS MER