Sökning: "expression of gender differences"

Visar resultat 16 - 20 av 60 avhandlingar innehållade orden expression of gender differences.

1. 16. Molecular genetics of type 2 diabetes

   Författare :Li Luosheng; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Type 2 diabetes; the Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; high fat diet; disease progression; alternative splicing; comparative genomics.;

   Sammanfattning : Type 2 diabetes is a common and chronic disease caused by interactions between genetic and environmental factors. The Goto-Kakizaki (GK) rat is a well-established genetic model of type 2 diabetes. LÄS MER

3. 17. Adaptability of skeletal muscle to hormone treatment in relation to gender and aging

   Författare :Fushun Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :skinned muscle fiber; gender; aging; steroid hormone; V0 electrophoresis; MyHC; MyLC; enzymehistochemistry; hyperthyroid rat; thyroid hormone receptor TR deficient TR[alpha]1 - -; TR[beta]- -; and TR[alpha]1- -[beta]- - mice;

   Sammanfattning : The aims of this study were to investigate the expression of myosin isoforms, muscle contractility at the cell level, and changes in these parameters in response to altered hormonal status in aging male and female rodents. In addition, by using mice lacking thyroid hormone receptors (TR[alpha]1 or TR[beta] or TR[alpha]1/[beta]) we tried to improve our understanding of the mechanisms by which thyroid hormone regulates the expression of specific MyHC isoforms via these different nuclear receptors. LÄS MER

4. 18. Sex Differences in Cardiac and Cerebral Damage after Hypovolemic Cardiac Arrest

   Författare :Egidijus Semenas; Sten Rubertsson; Lars Wiklund; Ala Nozari; Sven Erik Gisvold; Uppsala universitet; []
   Nyckelord :Cardiopulmonary resuscitation; sex; haemorrhage; neuronal damage; estradiol; hypertonic saline; nitric oxide; methylene blue; MEDICINE; MEDICIN; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård;

   Sammanfattning : Resuscitation from haemorrhagic shock and the subsequent circulatory arrest remains a major clinical challenge in the care of trauma patients. Numerous experimental studies in sexually mature animals have shown a gender dimorphism in response to trauma and haemorrhagic shock. LÄS MER

5. 19. Genetic studies of congenital upper limb anomalies

   Författare :Tobias Laurell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The overall aim of the work reported in this thesis is to improve epidemiological and genetic knowledge of congenital upper limb anomalies (CULA). To accomplish the specific aims of each paper several different methods and approaches have been used such as register studies, array comparative genome hybridization, Sanger sequencing, exome sequencing and functional studies using Lacz enhancer assay, Zebrafish morpholinos and computational transcription factor binding site prediction. LÄS MER

7. 20. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant

   Författare :Birgitta Houltz; Göteborgs universitet; []
   Nyckelord :Almokalant; class III antiarrhythmic agent; potassium channel blocker; atrial fibrillation; sinus rhythm; conversion; electrocardiographic; QT interval prolongation; T wave morphology; prediction; torsades de pointes; proarrhythmia; QT dispersion; ventric;

   Sammanfattning : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. LÄS MER