Sökning: "exposure-response relationships"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden exposure-response relationships.

  1. 1. Protein adducts in plasma as biomarkers of exposure to and risk of organic acid anhydrides

    Författare :Seema Rosqvist; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GC-MS; IgG; IgE; exposure-response; serum albumin; biological monitoring; Hexahydrophthalic anhydride; methylhexahydrophthalic anhydride; OEL; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : Organic acid anhydrides (OAAs) are important industrial chemicals but also potent inducers of airways diseases. Many exposed workers develop specific IgE and IgG antibodies. Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two particularly sensitising OAAs. LÄS MER

  3. 2. Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers

    Författare :Lena S Jönsson; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yrkesmedicin; arbetsmiljömedicin; industrial medicine; Public health; epidemiology; Folkhälsa; epidemiologi; Occupational health; Andningsorganen; rubber industry; polymorphisms; vulcanisation fumes; Respiratory system; nausea; headache; exposure-response relationships; biomarkers; symptoms; airways; eyes; TTCA; PAH; 1-hydroxypyrene;

    Sammanfattning : Workers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. LÄS MER

  4. 3. Pharmacometric Models to Improve the Treatment and Development of Drugs against Tuberculosis

    Författare :Robin J. Svensson; Ulrika S H Simonsson; Mats O Karlsson; Andreas Krause; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Biomarkers; Rifampicin; Clofazimine; Therapeutic drug monitoring; Time-to-event; Time-to-positivity; Molecular bacterial load assay; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : With 10 million new infections yearly, tuberculosis has a major impact on the human well-being of the world. Most patients have infections susceptible to a first-line treatment with a treatment success rate of 80%, a number that can potentially be improved by optimising the first-line treatment. LÄS MER

  5. 4. Pharmacokinetic-Pharmacodynamic Evaluations and Experimental Design Recommendations for Preclinical Studies of Anti-tuberculosis Drugs

    Författare :Chunli Chen; Ulrika Simonsson; Mats Karlsson; Sebastian Wicha; Bernd Meibohm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tuberculosis; pharmacokinetics; pharmacodynamics; pharmacometrics; the Multistate Tuberculosis Pharmacometric model; the General Pharmacodynamic Interaction model; optimized design; rifampicin; isoniazid; ethambutol; pyrazinamide; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Tuberculosis is an ancient infectious disease and a leading cause of death globally. Preclinical research is important for defining drugs and regimens which should be carried forward to human studies. LÄS MER

  7. 5. Occupational exposure to electromagnetic fields and chronic diseases

    Författare :Niclas Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Electromagnetic fields; chronic diseases; epidemiology; occupation; cancer diseases; neurodegenerative diseases; cardiovascular diseases.;

    Sammanfattning : This thesis consider two exposures from the electromagnetic spectrum extremely low-frequency magnetic fields (ELF MF) and ultraviolet (UV) radiation. ELF MF are the lowest and UV radiation ranges among the highest frequencies of non-ionizing radiation. The exposure prevalence of these fields is high in the general population. LÄS MER