Sökning: "experimental pancreatitis"

Visar resultat 11 - 15 av 15 avhandlingar innehållade orden experimental pancreatitis.

  1. 11. Chronic pancreatitis fibrogenesis : the role of TGFB pathway inhibitor Smad7 in the fibrosis development

    Författare :Xuan Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic pancreatitis is characterized by progressive inflammation, acinar atrophy and fibrosis. Transforming growth factor-B signaling (TGFB) is the most potent fibrogenic cytokine known, and its increased expression is a common denominator for fibrosis in chronic pancreatitis. LÄS MER

  3. 12. Role of platelets and neutrophils in regulating trypsinogen activation and tissue damage in acute pancreatitis

    Författare :Aree Abdulla; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Protease activation; adhesion molecule; chemokine; intravital flourecence microscopy; matrix metalloproteinase.;

    Sammanfattning : Acute pancreatitis is an inflammatory disease characterized by a diverse spectrum of clinical presentations ranging from a mild and self-limiting to a severe and systemic disorder. The relationship between inflammation and proteolytic activation in pancreatitis is an elusive issue. LÄS MER

  4. 13. Experimental septic shock – Effects of endotoxemia with special reference to pathophysiological responses in the pig

    Författare :Ewa Söderberg; Miklós Lipcsey; Mats B Eriksson; Anders Larsson; Jan Sjölin; Sten Lindahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endotoxin; inflammatory response; animal model; timing; steroid treatment; NGAL; Calprotectin; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Sepsis and septic shock are conditions, with severe outcome or in many cases death. Sepsis is a systemic inflammatory response trigger by bacteraemia but systemic inflammatory response can also be triggered by major trauma, major surgery, pancreatitis, severe burns etc. LÄS MER

  5. 14. Exploring disease biomarkers and mechanisms using metabolomics

    Författare :Anna Lindahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A metabolome is the complete set of small molecules or metabolites present in a biological system. It is the result of internal, genetically determined processes, as well as external factors. The metabolome can consequently be seen as an interface between the genome and the environment. LÄS MER

  7. 15. Intestinal ischemia and reperfusion. Proinflammatory response and organ dysfunction

    Författare :Knut Olanders; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatology; Kirurgi; ortopedi; traumatologi; orthopaedics; Surgery; inflammation; cytokine; leukocyte; reperfusion; ischemia; permeability; Intestine; endothelium;

    Sammanfattning : Intestinal I/R is considered to be an important initiating event in several pathophysiological conditions such as trauma, bleeding, sepsis and pancreatitis, frequently leading to concomitant both single and potentially multiple organ dysfunction. The purpose of this thesis was to study mechanims underlying the development of multiple organ dysfunction, with special focus on intercellular proinflammatory regulation in the concurrent development of tissue injury. LÄS MER