Sökning: "experimental glioma"

Visar resultat 1 - 5 av 36 avhandlingar innehållade orden experimental glioma.

1. 1. Malignant glioma : experimental studies with an estrogen-linked cytostatic

   Författare :Eva von Schoultz; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; malignant glioma; meningioma; glioma cells; sex steroids; estramustine; nor-nitrogen mustard; estramustine- binding protein; DNA damage; cell membrane;

   Sammanfattning : Malignant gliomas are the most common primary brain tumors in adults. Patients with these highly malignant tumors have an extremely poor prognosis. The situation with a highly proliferative tumor in a non-proliferating tissue should favor cytostatic treatment but so far the role of conventional chemotherapy has been adjunctive. LÄS MER

3. 2. Experimental therapies of malignant glioma : with emphasis on angiogenesis inhibition

   Författare :Maria Sandström; Roger Henriksson; Mikael Johansson; Anja Smits; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; angiogenesis; VEGF; tyrosinekinaseinhibitor; ZD6474; plasminogenactivator; tPA; uPA; proteomics; Oncology; Onkologi;

   Sammanfattning : Malignant glioma consists of a group of diseases where the localisation and the nature of the disease makes treatment an extreme challenge. Two important biological features of malignant glioma cells are their infiltrative growth and their ability to induce angiogenesis. LÄS MER

4. 3. Experimental studies on glioma cell motility and proliferation

   Författare :Adila Salih El-Obeid; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; glioma; TGF-α; EGFR; GFAP; motility; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : Glioma is a malignant primary brain tumor associated with short patient survival. Various growth factors and cytoskeletal proteins are correlated to glioma progression. In this thesis the effects of transforming growth factor alpha (TGFα) and glial fibrillary acidic protein (GFAP) were studied. LÄS MER

5. 4. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

   Författare :Ulrika Andersson; Roger Henriksson; Beatrice Malmer; Erik Blomquist; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; glioma; meningioma; endothelium; MDR; Pgp; MRP1; LRP; MGMT; EGFR; ErbB2; ErbB3; ErbB4; Onkologi; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. LÄS MER

7. 5. Expression of TGF- isoforms, their receptors and related SMAD proteins in brain pathology : Immunohistochemical studies focusing on infarcts, abscesses and malignant gliomas

   Författare :Ahmad Khaled Ata; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; TGF-beta receptor; SMAD; brain; infarct; abscess; glioma; experimental; human; Genetik; Clinical genetics; Klinisk genetik; Genetics; genetik;

   Sammanfattning : This thesis focuses on the immunohistochemical expression of transforming growth factor beta(TGFβ) isoforms, their receptors and TGF-β-related SMAD proteins in brain pathology, chiefly in-farcts. One key question was whether the expressions of these compounds are altered within glial cells, endothelial cells of microvessels and other cell types in the vicinity of infarcts. LÄS MER