Sökning: "experimental colitis"

Visar resultat 16 - 20 av 23 avhandlingar innehållade orden experimental colitis.

  1. 16. Genetic and molecular determinants in inflammatory bowel disease

    Författare :Francesca Bresso; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammatory Bowel Disease, IBD, are polygenic disorders that present itself to the clinician as a sum of interacting events arising from multiple factors of genetic, immunological and environmental origin, resulting in a chronic relapsing inflammation that manifests itself in two major forms, ulcerative colitis (UC) and Crohn Ls disease (CD). Shortage of reliable biomarkers for correct diagnosis and thus appropriate treatment regime is still a major problem for the clinically active physician. LÄS MER

  3. 17. Molecular markers and new techniques in the evaluation of colorectal cancer

    Författare :Claes Lenander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is ranked in the Western world as the third leading cause of death from malignant tumors. Despite improvements in early detection of the disease, new surgical techniques and adjuvant and neoadjuvant chemoradiation, more than 50% of these patients die within 5 years. LÄS MER

  4. 18. Inflammation and neutrophil recruitment in healing of colonic anastomosis

    Författare :Peter Månsson; Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; experimetnal; anastomotic healing; Inflammation; neutrophil redruitment; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Wound healing is a multistep process with an initial inflammatory response, followed by synthesis of extracellular matrix components and finalized by a repair phase. One main goal was to determine the impact and adhesive mechanisms of neutrophil recruitment in anastomotic healing in the colon. LÄS MER

  5. 19. Tartrate resistant acid phosphatase in the immune and nervous system : distribution and pathophysiological implications

    Författare :Pernilla Lång; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Tartrate resistant acid phosphatase (TRAP) belongs to the family of purple acid phosphatases (PAP). It is a glycoprotein synthesized as a monomer with low enzyme activity containing a redox active diiron centre in the active site. Post-translational proteolytic processing of this monomer into a dimeric protein increases the enzyme activity. LÄS MER

  7. 20. Multiple Functions of Glutathione Transferases : A Study on Enzymatic Function, Regulatory Role and Distribution in Mouse and Man

    Författare :Maryam Edalat; Joseph De Pierre; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; Biochemistry; Biokemi; biokemi; Biochemistry;

    Sammanfattning : To cope with various endogenous toxin and xenobiotics nature has equipped the organisms with a proper protection system. Glutathione transferases (GSTs) are important components of the cellular defense against oxidative stress. These proteins appear to be suited for different tasks. LÄS MER