Sökning: "exocrine secretion"
Visar resultat 16 - 20 av 22 avhandlingar innehållade orden exocrine secretion.
16. CFTR in pancreatic islets
Sammanfattning : AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. LÄS MER
17. FGFs and Wnts in pancreatic growth and β-cell function
Sammanfattning : Mesenchymal-epithelial interactions are pivotal for proper pancreatic growth and development. The pancreatic progenitor cells present in the early pancreatic anlagen proliferate and eventually give rise to all pancreatic cell types. LÄS MER
18. Studies on the phenotype of LXRβ-/- mice : from malabsorption to amyotrophic lateral sclerosis
Sammanfattning : Liver X Receptors, LXRalpha and LXRbeta (NR1H2) are nuclear receptors belonging to the superfamily of ligand-activated transcription factors with a key role in the control of lipid and glucose metabolism. Studies of the phenotype of LXRalpha-/-mice and LXRbeta-/-mice have shown that these nuclear receptors have specific and distinct roles, although they share very high sequence homology (78%). LÄS MER
19. Acute Pancreatitis. Studies on smoking and protease activation
Sammanfattning : Background and aims: Activation of pancreatic proteases is considered to be a crucial event in the early phase of acute pancreatitis but the cause of this activation is not known. Most cases of acute pancreatitis can be attributed to either gallstone disease or alcohol abuse. However, little is known about other risk factors. LÄS MER
20. LXR and aromatase knock-out mice : animal models providing insight into human diseases
Sammanfattning : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. LÄS MER
