Sökning: "exhaustion"

Visar resultat 21 - 25 av 166 avhandlingar innehållade ordet exhaustion.

1. 21. Potential immunoregulatory role of T and dendritic cells in cancer : Investigations based on transcriptional analysis

   Författare :Milad Abolhalaj; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic cells; T cells; head and neck cancer; acute myeloid leukemia; bladder cancer; T cell exhaustion;

   Sammanfattning : Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. LÄS MER

3. 22. Roller skis' rolling resistance and grip characteristics : influences on physiological and performance measures in cross-country skiers

   Författare :Mats Ainegren; Peter Carlsson; Marko Laaksonen; Mittuniversitetet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Adjustable grip; blood lactate; centre of pressure; cycle length; cycle rate; economy; efficiency; friction coefficient; heart rate; normal force; OBLA; oxygen uptake; power; ratcheted wheel; ratings of perceived exertion; roller skis; rolling resistance; tangential force; time to exhaustion;

   Sammanfattning : The aim of this thesis was to investigate roller ski characteristics; classical and freestyle roller skis’ rolling resistance coefficients (μR) and classical style roller skis’ static friction coefficients (μS), and to study the influence of different μR and μS on cross-country skiers’ performance and both physiological and biomechanical indices. The aim was also to study differences in skiing economy and efficiency between recreational skiers, female and male junior and senior elite cross-country skiers. LÄS MER

4. 23. Studies of the Boundary Behaviour of Functions Related to Partial Differential Equations and Several Complex Variables

   Författare :Håkan Persson; Kaj Nyström; Maciej Klimek; Evgeny Poletsky; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; uniformly parabolic equations; non-linear parabolic equations; linear growth; Lipschitz domain; NTA-domain; Riesz measure; boundary behavior; boundary Harnack; degenerate parabolic; parabolic measure; plurisubharmonic functions; continuous boundary; hyperconvexity; bounded exhaustion function; Hölder for all exponents; log-lipschitz; boundary regularity; approximation; Mergelyan type approximation; plurisubharmonic functions on compacts; Jensen measures; monotone convergence; plurisubharmonic extension; plurisubharmonic boundary values; Mathematics; Matematik;

   Sammanfattning : This thesis consists of a comprehensive summary and six scientific papers dealing with the boundary behaviour of functions related to parabolic partial differential equations and several complex variables.Paper I concerns solutions to non-linear parabolic equations of linear growth. LÄS MER

5. 24. CAR T cells for Immunotherapy of Cancer

   Författare :Tina Sarén; Magnus Essand; Martin Pule; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Chimeric antigen receptor CAR -T cells; Cancer immunotherapy; NAP; Tonic signaling; T cell exhaustion; B cell lymphoma; clinical trial; glioblastoma;

   Sammanfattning : In recent years, immunotherapy has revolutionized cancer treatment by prolonging survival and even curing patients lacking other available therapies. Besides immune checkpoint inhibitors, one of the major advances is attributed to the success of chimeric antigen receptor (CAR)-T cell therapy in treating patients with B-cell malignancies. LÄS MER

7. 25. Immune deterioration in HIV-1 and HIV-2 infection with a focus on CD8 T cell exhaustion

   Författare :Lydia Scharf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Thanks to the development of antiretroviral treatment (ART), human immunodeficiency virus (HIV) infection is now considered a chronic infection rather than the death sentence it used to be. Despite constant expansion and improvement of treatment options, even optimal therapy cannot prevent the impact of HIV on the human immune system. LÄS MER