Sökning: "exendin"

Visar resultat 1 - 5 av 23 avhandlingar innehållade ordet exendin.

  1. 1. [68Ga]Exendin-4: Bench-to-Bedside : PET molecular imaging of the GLP-1 receptor for diabetes and cancer

    Författare :Ram kumar Selvaraju; Olof Eriksson; Olle Korsgren; Lars Johansson; Martin Gotthardt; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; [68Ga]Exendin-4; beta cell imaging; insulinoma; dosimetry;

    Sammanfattning : Diabetes epidemic is underway. Beta cell dysfunction (BCF) and loss of beta cell mass (BCM) are known to be key events in its progression. Currently, there are no reliable techniques to estimate or follow the loss of BCM, in vivo. LÄS MER

  3. 2. Microencapsulation of Pancreatic Islets : A Non-Vascularised Transplantation Model

    Författare :Sara Bohman; Arne Andersson; Aileen King; Stellan Sandler; Eduard Montanya; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Microencapsulation; Islet transplantation; revascularisation; alpha-cell; exendin-4; islet amyloid; Cell biology; Cellbiologi;

    Sammanfattning : Transplantation of pancreatic islets is a potential treatment of type 1 diabetes that aims to restore normal blood glucose control. By encapsulating the islets in alginate, they can be protected from rejection. LÄS MER

  4. 3. Engraftment of Pancreatic Islets in Alternative Transplantation Sites and the Feasibility of in vivo Monitoring of Native and Transplanted Beta-Cell Mass

    Författare :Daniel Espes; Per-Ola Carlsson; Joey Lau; Mia Phillipson; Eelco de Koning; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Islet transplantation; Alternative implantation sites; Exendin-4; Positron Emission Tomography; 5-hydroxy tryptophan; Beta-cell mass; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Islet transplantation is a possible curative treatment for type 1 diabetes (T1D). Currently the liver dominates as implantation site, despite the many challenges encountered at this site.Acute hypoxia in islets transplanted to muscle and omentum, two possible alternative sites, was prevailing. LÄS MER

  5. 4. Inflammatory Mechanisms of Depression and Suicidal Behavior

    Författare :Filip Ventorp; Lund Psykiatri; []
    Nyckelord :INFLAMMATION; Depression; Suicid; CD44; Hyaluronan; exendin-4; Kemokiner; Fluoxetin;

    Sammanfattning : .... LÄS MER

  7. 5. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

    Författare :Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

    Sammanfattning : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. LÄS MER