Sökning: "excitotoxicity"

Visar resultat 6 - 10 av 21 avhandlingar innehållade ordet excitotoxicity.

  1. 6. Inflammation and ischemia in the developing brain - modifying effects of hyperoxia and adrenoceptor activation

    Detta är en avhandling från Department of Pediatrics, Lund University

    Författare :Tina Markus; Lunds universitet.; Lund University.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenergic; preconditioning; excitotoxicity; tissue culture; hyperoxia; resuscitation; asphyxia; sensitization; TNF-alpha; inflammatory mediators; hippocampus; neonate;

    Sammanfattning : Inflammation and ischemia are common causes of perinatal brain damage. Ventilation with pure oxygen has previously been the prime choice during resuscitation following fetal asphyxia. LÄS MER

  2. 7. Neuroprotection in the Injured Spinal Cord Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Nikos Schizas; Uppsala universitet.; [2015]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronic Acid-based hydrogel; motorneurons; microglial cells; Interleukin-1 Receptor Antagonist; Renshaw cells; excitotoxicity; neuroinflammation; Neural Crest Stem Cells; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. LÄS MER

  3. 8. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity

    Detta är en avhandling från Göteborg

    Författare :Camilla Wallin; Göteborgs universitet.; Gothenburg University.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glutathione; excitotoxicity; hypoxia-ischemia; brain; rat; anoxia-aglycemia; g-glutamyl transpeptidase; glutamate; NMDA; oxidative stress; mitochondria; amino acids;

    Sammanfattning : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. LÄS MER

  4. 9. Neuronal apoptosis in excitotoxicity : involvement of nitric oxide and cytoskeletal damage

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Emanuela Bonfoco; Karolinska Institutet.; Karolinska Institutet.; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In the nervous system apoptosis may play an important role in the development of several neurodegenerative diseases. The overall objective of the present work is to investigate at the cellular and molecular levels, the mechanisms by which neurons are signalled to undergo apoptotic cell death after exposure to various effectors, such as nitric oxide (NO) and its by- products, glutamate, and colchicine. LÄS MER

  5. 10. Protection of Striatal and Nigral neurons by Trophic and Antioxidant Mechanisms. A study on in vitro and in vivo brain insult models and neural transplants

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Naoyuki Nakao; [1996]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lazaroids; NT-3; BDNF; PDGF; IGF; FGF; dopamine; DARPP-32; cell culture; hypoglycemia; ischemia; oxygen free radicals; neural transplantation. excitotoxicity; Huntington s disease; Parkinson s disease; a-phenyl-tert-butyl nitrone; N-methyl-D-aspartate; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : This thesis explored the protective effects of growth factors and antioxidants on striatal and nigral neurons in in vitro and in vivo brain insult models and neural transplants. Five different growth factors were examined for their survival-promoting effects on cultured striatal neurons: basic fibroblast growth factor (bFGF), truncated insulin-like growth factor-1 (tIGF-1), platelet derived growth factor (PDGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3). LÄS MER