Sökning: "excess cancer risk"

Visar resultat 1 - 5 av 92 avhandlingar innehållade orden excess cancer risk.

  1. 1. Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds

    Författare :Jenny Aasa; Margareta Törnqvist; Elaine M. Faustman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glycidol; 3-monochloropropane-1; 2-diol 3-MCPD ; genotoxicity; mutations; micronuclei; hemoglobin adducts; in vivo dose; multiplicative risk model; cancer risk assessment; human cancer risk; miljökemi; Environmental Chemistry;

    Sammanfattning : Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glycidol, which is genotoxic and an animal carcinogen. It is the model compound of this work, partly due to its presence in food. LÄS MER

  3. 2. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

    Författare :Susanne Magnusson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancer; hereditary factors; breast cancer; survival; hereditary breast and ovarian cancer; hereditary non-polyposis colorectal cancer; familial malignant melanoma; BRCA1; BRCA2; mismatch repair; CDKN2A; familial risk; multiple childhood tumors; Li-Fraumeni syndrome; TP53; adrenocortical carcinoma; choroid plexus tumors; rhabdomyosarcoma;

    Sammanfattning : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. LÄS MER

  4. 3. Obesity, Adipocytes and Breast Cancer – Insights from Translational Studies

    Författare :Malin Bergqvist; Bröstcancer - prevention & intervention; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast Cancer; Breast cancer risk; Breast cancer prognosis; Obesity; Adipocyte; Adipokines; CAP; Neutrophil to lymphocyte ratio;

    Sammanfattning : Background: Being overweight is becoming the new normal, and more than half of the adult Swedish population is overweight which poses a risk to public health. Overweight and obese women have both an increased risk and a worse prognosis for breast cancer, compared with women of normal weight. LÄS MER

  5. 4. Mismatch repair deficiency in colorectal cancer : prognosis and prediction for basic treatment strategies

    Författare :Ioannis Gkekas; Jan Novotny; Karin Strigård; Richard Palmqvist; Ulf Gunnarsson; Christian Sturesson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; defective mismatch repair; prognosis and prediction; Oncology; onkologi;

    Sammanfattning : Colorectal cancer (CRC) remains a significant healthcare problem worldwide, being the third most common cancer and the fourth most frequent cause of cancer death. Environmental and dietary factors such as alcohol abuse, cigarette smoking, and genetic predisposition seem to constitute the main aetiologies. LÄS MER

  7. 5. Methodological aspects on excess cancer riskafter exposure to ionizing radiation

    Författare :Erik Holmberg; Göteborgs universitet; []
    Nyckelord :ionizing radiation; skin haemangioma; breast cancer; parathyroid adenoma; excess cancer risk; bias; confounding; risk models; pooled analysis.;

    Sammanfattning : Aims. The aims of this study were to establish a cohort of persons treated with radiotherapy for skin haemangioma in childhood and study the excess risk of cancer after exposure to ionizing radiation. LÄS MER