Sökning: "ewing sarcoma"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden ewing sarcoma.

  1. 1. Ewing sarcoma : treatment, prognosis and late effects

    Författare :Asle Charles Hesla; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Ewing sarcoma (ES) is a rare and aggressive childhood/adolescent malignancy which relies on a multidisciplinary treatment approach for cure. The overall survival rate for this young patient group has hardly improved over the last 30 years despite large multinational treatment trials. LÄS MER

  3. 2. FET fusion oncoproteins in sarcoma tumorigenesis - lnteractions with the SWI/SNF chromatin remodeling complex and epigenetic effects

    Författare :Malin Lindén; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ewing sarcoma; Epigenetics; FET fusion oncoproteins; Myxoid liposarcoma; Proteomics; SWI SNF BAF chromatin remodeling complex;

    Sammanfattning : The FET family of fusion oncoproteins containing the N-terminal of either FUS, EWSR1 or TAF15 together with a transcription factor partner is the characteristic oncogenic driver of more than 20 types of sarcoma and leukemia, including myxoid liposarcoma and Ewing sarcoma. The FET oncoproteins are thought to function as aberrant transcription factors, however, the exact oncogenic mechanism remains to be elucidated. LÄS MER

  4. 3. Comparative treatment planning in external radiotherapy of malignant tumours : Potential gains using protons

    Författare :Ulf Isacsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Breast cancer; comparative treatment; Ewing sarcoma; oesophageal cancer; protontherapy; radiotherapy; rectal cancer; treatment planning algorithms; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : It is well known that protons have physical characteristics superior to conventional radiation qualities in external beam radiotherapy. The primary aim of this work is to determine if the physical advantages also may lead to clinical advantages. LÄS MER

  5. 4. Sarcoma ecosystems : spatial characterization and prognostic significance

    Författare :Yanhong Su; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Sarcoma is a highly heterogeneous disease with complex biological activities and unique tumor microenvironments (TME) in distinct subtypes. The limited treatment options and inadequate responses to current therapies necessitate a deeper understanding of sarcoma biology and personalized treatment strategies. LÄS MER

  7. 5. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects

    Författare :Gunnar Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ewing s sarcoma; synovial sarcoma; translocation; fusion gene; fusion protein; diagnosis and prognosis;

    Sammanfattning : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. LÄS MER