Sökning: "evolved mutation rates"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden evolved mutation rates.

1. 1. Mathematical Models of Molecular Evolution

   Författare :Martin Nilsson; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; dynamic fitness landscapes; quasispecies; error thresholds; evolved mutation rates; evolution in dynamic environments;

   Sammanfattning : This thesis deals with mathematical models of Darwinian evolution in populations of simple living organisms. We study models which describe how the representation of different gene sequences in the population is affected by the fundamental forces of evolutionary processes, such as selection pressure, the mutation rate and the time dynamics of the underlying fitness landscape. LÄS MER

3. 2. Bacterial Resistance to Antimicrobial Peptides : Rates, Mechanisms and Fitness Effects

   Författare :Maria Pränting; Dan Andersson; Ian Chopra; Uppsala universitet; []
   Nyckelord :antimicrobial peptides; antibiotic resistance; fitness cost; bacterial evolution; small colony variants; cyclotides; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Mikrobiologi; Microbiology;

   Sammanfattning : The rapid emergence of bacterial resistance to antibiotics has necessitated the development of alternative treatment strategies. Antimicrobial peptides (AMPs) are important immune system components that kill microbes rapidly and have broad activity-spectra, making them promising leads for new pharmaceuticals. LÄS MER

4. 3. Geographic and genetic diversity of hepatitis B

   Författare :Erik Alestig; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis B virus; genotype; phylogeny; molecular epidemiology; sequence analysis; mutation;

   Sammanfattning : Hepatitis B Virus (HBV) infection is a global health problem and may lead to chronic hepatitis, liver cirrhosis and hepatocellular cancer. The ability of HBV to adapt to the host environment by genetic variation has lead to the evolution of 8 established (A-H) and 2 putative genotypes (I-J), each corresponding to a rather well-defined geographical distribution. LÄS MER

5. 4. Bacterial adaption to novel selection pressures

   Författare :Annika Nilsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Evolution; bacterial adaptation; mutation rate; population size; mutation accumulation; fitness; antibiotic resistance; compensation; genetic drift; genome reduction;

   Sammanfattning : The rates and trajectories of bacterial evolution are determined both by microbial factors and environmental parameters. In this thesis 1 have investigated how bacterial mutation rates and selection pressure affect the rate and extent of adaptation to novel environments. LÄS MER

7. 5. Computational studies of mutational sequence signatures in cancer genomes

   Författare :Markus Lindberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Genomcis; Mutational signatures; Ultraviolet light; Multifocal tumors;

   Sammanfattning : Cancer typically forms when mutational processes modify key cancer driver genes, resulting in positive selection and tumor growth. As such, mutational processes are at the core of the disease. Trinucleotide mutational signatures have emerged in the last decade as essential tools for analysis of mutational processes. LÄS MER