Sökning: "evolution of innate immunology"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden evolution of innate immunology.

  1. 1. Pathogen-mediated selection in the immune system of rodents : Exploring selection targets, functional effects and trade-offs

    Författare :Mridula Nandakumar; Funktionell zoologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; pathogen-mediated selection; bank voles; Myodes glareolus; immune system; balancing selection; immune response; rodents; positive selection; transcriptomics;

    Sammanfattning : Pathogens cause disease and play an important role in shaping evolution of the host immune system. They create pressure on host immunity to evolve in numerous ways, most commonly by increasing divergence between species (positive selection) or increasing polymorphisms within a population (balancing selection). LÄS MER

  3. 2. Mechanisms of microbial-host interaction during asymptomatic bacteriuria

    Författare :Jenny Grönberg Hernandez; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asymptomatic bacteriuria; Urinary tract infection; Escherichia coli 83972; IRF3; TLR4; Evolution; host response; promoter polymorphisms; transcription; P fimbriae; Type 1 fimbriae;

    Sammanfattning : Urinary tract infections (UTIs) present an interesting and relevant model for studying microbial adaptation. After establishing significant numbers, the bacteria either cause severe disease, or an asymptomatic carrier state resembling the normal flora at other mucosal sites. LÄS MER

  4. 3. Defence on Demand : A physiological perspective on phenotypic plasticity in anti-predator traits

    Författare :Jerker Vinterstare; Enhet akvatisk ekologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phenotypic plasticity; inducible defences; stress physiology; cortisol; immune function; trade-offs; sexual dimorphism; crucian carp; visual ecology; predator-prey interactions; POMC pro-opiomelanocortin ; colour change; eco-immunology; Anti-predator defences; Inducible morphological defence; Phenotypic plasticity; Stress physiology; Cortisol; Immune function; Crucian carp; Predator-prey interactions; Trade-offs; Sexual dimorphism; POMC; Pro-opiomelanocortin; Visual ecology; Eye evolution; Melanin; Eco-immunology; Pace-of-life; Behavioural plasticity;

    Sammanfattning : Almost all species face some degree of predation risk, and, hence, evolution has produced a plethora of anti-predator defences. However, anti-predator strategies require resources, and the prevailing risk of becoming prey is influenced by many factors and rarely constant across time and space. LÄS MER

  5. 4. Costs in the ecology and evolution of the vertebrate immune system

    Författare :Lars Råberg; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cost of resistance; ecological immunology; immunocompetence; Parus caeruleus; transgenic mice; Animal ecology; Djurekologi; blue tit; basal metabolic rate;

    Sammanfattning : A central assumption of theories of the ecology and evolution of immunological defence is that defence has not only benefits (in the form of resistance against parasites), but also costs. The aim of my studies was to investigate the nature and magnitude of costs of the vertebrate immune system, and to examine some of the consequences of these costs. LÄS MER

  7. 5. Eco-immunological studies of innate immunity in Mallards (Anas platyrhynchos)

    Författare :Anu S. Helin; Jonas Waldenström; Edwin Veldhuizen; Linnéuniversitetet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Avian β-defensins AvBDs ; Avian gene expression; Host-pathogen interactions; Innate immunity; Mallard Anas platyrhynchos ; Myxovirus resistance gene Mx ; Retinoic acid inducible gene 1 RIG-I ; Avian β-defensins AvBD ; Genuttryck; Gräsand Anas platyrhynchos ; Immunförsvar; Immungener; Myxovirus resistant gene Mx ; Patogen; Retinoic acid inducible gene 1 RIG-I ; Ecology; Ekologi;

    Sammanfattning : This thesis comprises two sections, both of which explore eco-immunology of the innate immune system of mallards (Anas platyrhynchos). The innate immune system serves a pivotal role as the first line of defense against invading pathogens, and is comprised of physical and chemical barriers. LÄS MER