Sökning: "estrogens"
Visar resultat 16 - 20 av 106 avhandlingar innehållade ordet estrogens.
16. Some hormonal factors in the etiology of endometrial cancer
Sammanfattning : The main purpose of this dissertation was to study the impact of some hormone-related factors in the etiology of endometrial neoplasms, i.e. hormone replacement therapy, use of oral contraceptives, serum levels of 20 different organochlorine substances, and polymorphisms in the estrogen receptor alpha (ER) gene. LÄS MER
17. An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors
Sammanfattning : The main purpose of this thesis was to examine estrogen and progestin effects of hormone replacement therapy, in relation to the risk for epithelial ovarian neoplasias. Other intentions were to assess reproductive factors, oral contraceptive use, previous gynecologic surgeries, and family history of ovarian cancer according to the risk of ovarian neoplasias, and to connect these findings to different hypotheses regarding ovarian carcinogenesis. LÄS MER
18. Breast cancer epidemiology : influence of hormone-related factors
Sammanfattning : The main purpose of this thesis was to explore how hormone-related factors, including use of hormone replacement therapy and oral contraceptives, body size in different periods of life and reproductive factors, influence the risk of breast cancer. Other aims were to assess how family history of breast cancer modifies the associations between such factors and risk of the disease and how hormone replacement therapy affects tumour characteristics. LÄS MER
19. Does cancer originate in utero?
Sammanfattning : The purpose of the present thesis was to evaluate Trichopoulos' hypothesis that breast cancer can originate in utero, and to examine the role of antenatal estrogen exposure in the etiology of testicular cancer. First, we used data from a Swedish-Norwegian cohort study on risk factors for small-for-gestational-age births to identify markers for antenatal estrogen exposure. LÄS MER
20. Challenges in experimental stroke research : The 17β-estradiol example
Sammanfattning : Ischemic stroke causes millions of deaths around the world each year, and surviving patients often suffer from long-term disability. Hundreds of promising drug candidates have been identified in animal models, but the clinical trials have repeatedly failed. Lack of methodological quality in the animal studies, e.g. LÄS MER