Sökning: "estrogen receptor beta"

Visar resultat 21 - 25 av 62 avhandlingar innehållade orden estrogen receptor beta.

  1. 21. Role of estrogen receptor beta in mouse ventral prostate with relation to human prostatic diseases

    Författare :Otabek Imamov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In this thesis we investigate role of estrogen receptor beta (ERbeta) in development and functioning of mouse ventral prostate, using it as a model for human extrapolations. ERbeta was discovered in 1995 and is a member of a nuclear receptors superfamily, acting as a transcription factor for steroid hormone signaling. LÄS MER

  3. 22. Role of estrogen receptor beta in mouse prostate and bladder with references to human diseases

    Författare :Otabek Imamov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : After the discovery of estrogen receptor beta (ERbeta) in 1995, it became clear that in many non-classical estrogen-responsive organs, were in fact direct targets for estrogen. One of these organs is prostate gland, where ERbeta is abundant in epithelium. LÄS MER

  4. 23. Validation of antibodies for tissue based immunoassays

    Författare :Sandra Andersson; Anna Asplund; Fredrik Pontén; Kenneth Wester; Mike Taussig; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibody validation; Conjugation; Estrogen receptor-beta; IHC; ISH; Lymphohematopoietic tissues; Proteomic; RNAseq; TMA; Transcriptomic; Patologi; Pathology;

    Sammanfattning : In situ protein detection in human tissues using antibodies reveals the cellular protein localization, and affinity-based proteomic studies can help to discover proteins involved in the development of diseases. However, antibodies often suffer from cross-reactivity, and the lack of positive and negative tissue controls for uncharacterized proteins complicates the mapping of the proteome. LÄS MER

  5. 24. Functions of estrogen receptor b in the metabolism of rodent bone

    Författare :Sara Windahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogens are important for widespread biological functions including regulation of development and maintenance of skeletal tissue. The effects of estrogens are thought to be mediated via two intracellular proteins, estrogen receptors a and beta (ERalpha and ERbeta , respectively), which are expressed in most cell types in bone. LÄS MER

  7. 25. Molecular mechanisms of estrogen and antiestrogen action

    Författare :Tomas Barkhem; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; SHBG; tamoxifen; raloxifene; pS2; p1 60 coactivator; SRC-1; TIF-2;

    Sammanfattning : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. LÄS MER