Sökning: "estrogen deficiency"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden estrogen deficiency.

  1. 11. Studies on gender-specific disruption of bone tissue homeostasis by dioxins

    Författare :Carolina Wejheden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Dioxins are widespread environmental pollutants, known to cause immunosuppression, developmental and reproductive defects, as well as cancer. The toxic effects of dioxins are mediated by the aryl hydrocarbon receptor (AhR, also referred to as the dioxin receptor). LÄS MER

  3. 12. Identifying genetic determinants of T cell-dependent autoimmunity using forward genetics

    Författare :Gonzalo Fernandez Lahore; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) affects 0.5-1% of the population and is an important health and socioeconomic problem. RA has a high degree of heritability. Thus, extensive efforts have been made to better understand the genetic variability contributing to disease susceptibility. LÄS MER

  4. 13. Osteoporosis, a major health problem in Vietnam : life style factors and determinants of bone mass

    Författare :Thi Thanh Huong Nguyen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vietnamese men and women;

    Sammanfattning : While the prevalence of osteoporosis and risk factors for low bone mineral density (BMD) has been well documented in Caucasian populations, there is a lack of data from Asia. This work was designed to clarify to what extent osteoporosis could be regarded as a major public health problem in Vietnam. LÄS MER

  5. 14. The role of S100A4 protein as a regulator of inflammation and bone metabolism in experimental arthritis

    Författare :Li Bian; Göteborgs universitet; []
    Nyckelord :S100A4; arthritis; animal model; bone; inflammation;

    Sammanfattning : S100A4 belongs to the family of calcium-binding S100 proteins and modulates cell proliferation, cytoskeletal rearrangement, cell motility, and angiogenesis. Increased levels of S100A4 expression correlate with high incidence of metastasis of cancers. LÄS MER

  7. 15. Effects of antiresorptive agents on inflammation and bone regeneration in different osseous sites - experimental and clinical studies

    Författare :Carina Cardemil; Peter Thomsen; Cecilia Larsson Wexell; Bente Brokstad Herlofson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Qntiresorptive agents; ovariectomised rat; osteoporosis; skeletal site; differences osteonecrosis of the jaw; osseointegration; bone substitute; inflammation; bone regeneration; gene expression; histomorphometry; Micro-CT; antiresorptive agents; ovariectomised rat; osteoporosis; skeletal site differences; osteonecrosis of the jaw; osseointegration; bone substitute; inflammation; bone regeneration; gene expression; histomorphometry; Micro-CT;

    Sammanfattning : The biological mechanisms involved in bone regeneration in osteoporotic bone and the effect of antiresorptive drugs in relation to surgically inserted biomaterials are not fully understood. Improved osseointegration of titanium implants but also adverse effects of antiresorptive therapies, such as osteonecrotic jaw have been described in the literature. LÄS MER