Sökning: "erbb2 erbb3"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden erbb2 erbb3.

  1. 1. Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications

    Författare :Mikael Åstrand; Sophia Hober; John Löfblom; Larry Gold; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ABD; ADAPT; Protein G; ERBB2; ERBB3; Directed evolution; phage display; staphylococcal display; bispecific; Bioteknologi; Biotechnology;

    Sammanfattning : Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. LÄS MER

  3. 2. Experimental studies in brain tumours : with special regard to multidrug resistance and the ErbB-family

    Författare :Ulrika Andersson; Roger Henriksson; Beatrice Malmer; Erik Blomquist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; glioma; meningioma; endothelium; MDR; Pgp; MRP1; LRP; MGMT; EGFR; ErbB2; ErbB3; ErbB4; Onkologi; Oncology; Onkologi; onkologi; Oncology;

    Sammanfattning : Primary brain tumours, and especially the most common form malignant gliomas, usually display a pronounced resistance to other treatment modalities when surgery fails to cure. Growth factors, such as EGF and its receptor, frequently amplified and overexpressed in malignant gliomas, and factors associated with multidrug resistance have been suggested to at least partially explain the poor outcome. LÄS MER

  4. 3. An albumin-binding domain as a scaffold for bispecific affinity proteins

    Författare :Johan Nilvebrant; Sophia Hober; Andrew Bradbury; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; albumin-binding domain; bispecific; albumin; affinity protein; phage display; staphylococcal display; orthogonal affinity purification; TNF-alpha; ErbB2; ErbB3; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Sammanfattning : Protein engineering and in vitro selection systems are powerful methods to generate binding proteins. In nature, antibodies are the primary affinity proteins and their usefulness has led to a widespread use both in basic and applied research. LÄS MER

  5. 4. Novel Roles of the Ack1 Kinase in Epithelial Biology

    Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

  7. 5. Studies of LRIG1 and the ERBB receptor family in breast and colorectal cancer

    Författare :Ingrid Ljuslinder; Beatrice Malmer; Håkan Hedman; Roger Henriksson; Irina Golovleva; Mef Nilbert; Umeå universitet; []
    Nyckelord :breast cancer; colorectal cancer; LRIG1; EGFR; ERBB2; invasive margin; onkologi; Oncology;

    Sammanfattning : The LRIG1 gene (leucine-rich repeats and immunoglobulin like domains-1) at chromosome 3p14 is a proposed tumour suppressor gene whose gene product negatively regulates various receptor tyrosine kinases. This function has been the basis for classifying LRIG1 as a potential tumour suppressor gene (TSG). LÄS MER