Sökning: "epithelial"

Visar resultat 6 - 10 av 1038 avhandlingar innehållade ordet epithelial.

1. 6. Pathogenic Neisseria infections of human neutrophils and epithelial cells : focusing on host responses and immune evasion

   Författare :Niklas Söderholm; Helena Aro; Thomas Rudel; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neisseria meningitidis; Neisseria gonorrhoeae; Neutrophils; PMN; Epithelial cells; Polarized cells; Type IV pili; Adherence; Cell cycle; DNA damage; Lactobacillus; molekylär biovetenskap; Molecular Bioscience;

   Sammanfattning : N. meningitidis and N. gonorrhoeae are obligate human pathogens that colonize mucosal surfaces and are often carried asymptomatically. These bacteria have developed adhesive structures that promote adherence to host cells and efficient colonization of new hosts. LÄS MER

3. 7. Novel Roles of the Ack1 Kinase in Epithelial Biology

   Författare :Giulia Pilia; Ingvar Ferby; Bengt Hallberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ack1; Epithelial homeostasis; Cell Signalling; Cancer; Apoptosis; TRAIL-R; Yap Taz; Mechanotransduction; ErbB3; Molekylär cellbiologi; Molecular Cellbiology;

   Sammanfattning : Epithelial homeostasis is maintained through integration of diverse signals that regulate cell fate. A strict control of such signals is required to prevent overproliferation and, ultimately, oncogenesis. In this thesis we identify novel roles of Activated Cdc42-associated kinase 1 (Ack1) in maintenance of epithelial homeostasis. LÄS MER

4. 8. Epithelial signatures in respiratory disease

   Författare :Elisabeth Ax; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; airway epithelium; inflammation; gene expression; extracellular vesicles; miRNA;

   Sammanfattning : The epithelium of the human airways protects us against harm and helps maintain immune homeostasis. In respiratory diseases such as asthma and COPD, the functions of the epithelium are altered and can cause or contribute to disease progression. LÄS MER

5. 9. Sensory mechanisms in the human upper airway - Role of TRP ion channels

   Författare :Lisa Alenmyr; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRPV1; TRPV4; TRPA1; allergic rhinitis; itch; rhinorrhea; MUC5B; MUC5AC; epithelial;

   Sammanfattning : The nasal mucosa is richly innervated with sensory nerves having the ability to detect changes in the environment and mediate symptoms such as secretion and itch. Some TRP ion channels such as TRPV1 and TRPA1 are abundantly expressed in sensory nerves and respond to a wide variety of stimuli, including irritants, inflammatory mediators and temperatures. LÄS MER

7. 10. Translational studies of epithelial cancer

   Författare :Johanna Classon; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tumors stemming from specialized epithelial cells cause the most common cancer types and are among the leading causes of death in the western world. Although great strides have been made in early cancer detection, defining prognostic factors, and improving survival with novel treatments, cancers such as colorectal cancer and prostate cancer are incurable in their advanced stages. LÄS MER