Sökning: "epithelial-mesenchymal transition emt"
Visar resultat 1 - 5 av 27 avhandlingar innehållade orden epithelial-mesenchymal transition emt.
1. Molecular factors influencing epithelial-mesenchymal transition in breast cancer
Sammanfattning : Epithelial-mesenchymal transition (EMT) is a developmental process defined by loss of epithelial characteristics and acquisition of mesenchymal phenotype. EMT or similar processes are also implicated in carcinoma cell invasion and the progression of breast carcinoma to metastasis. LÄS MER
2. Transcriptional and Epigenetic Regulation of Epithelial-Mesenchymal Transition
Sammanfattning : The transforming growth factor beta (TGFβ) is a cytokine that regulates a plethora of cellular processes such as cell proliferation, differentiation, migration and apoptosis. TGFβ signals via serine/threonine kinase receptors and activates the Smads to regulate gene expression. LÄS MER
3. Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
Sammanfattning : Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. LÄS MER
4. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors
Sammanfattning : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. LÄS MER
5. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis
Sammanfattning : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. LÄS MER