Sökning: "epithelial surfaces"

Visar resultat 21 - 25 av 44 avhandlingar innehållade orden epithelial surfaces.

  1. 21. Multifunctional biomimetic materials for corneal regeneration

    Författare :Mohammad Mirazul Islam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cornea is the outermost layer of the eye, which is responsible for transmitting 95% of the incident light to the retina for vision and provides 70% of the focusing power of the eye. Corneal disease is a primary cause of blindness worldwide. LÄS MER

  3. 22. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

    Författare :Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. LÄS MER

  4. 23. Molecular and cellular mechanisms during adherence and cell signaling of pathogenic Neisseria to host cells

    Författare :Helena Källström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neisseria; pili; adhesion; PiIC; CD46; signaling; G-protein;

    Sammanfattning : The pathogenic members of the genus Neisseria include N. gonorrhoeae and N. meningitidis. Both organisms are obligate human pathogens that colonize mucosal surfaces. LÄS MER

  5. 24. Multifaceted adhesion properties of Helicobacter pylori in promotion of gastric disease

    Författare :Jenny Nordén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Helicobacter pylori is a Gram-negative spiral-shaped bacteria that resides in the gastric mucosa and adheres to the epithelial lining of the human stomach. H. pylori adhesion mediates inflammation of the epithelium, which can lead to more severe diseases such as chronic active gastritis and gastric carcinoma. LÄS MER

  7. 25. On the role of HMGB1 and IL-1 in tissue barrier defense

    Författare :Cecilia Zetterström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The specialized epithelial surfaces of the lymphoepithelial tissue in the airways and the seminiferous epithelium of the testis are sites of host-environmental interaction at the same time as they serve important physiological functions in gas exchange and reproduction. The host response of a broken epithelial barrier requires rapid mechanisms to control the microflora and to prevent invasion of pathogens. LÄS MER