Sökning: "epithelial surfaces"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden epithelial surfaces.

  1. 1. Pathogenic Neisseria infections of human neutrophils and epithelial cells : focusing on host responses and immune evasion

    Författare :Niklas Söderholm; Helena Aro; Thomas Rudel; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Neisseria meningitidis; Neisseria gonorrhoeae; Neutrophils; PMN; Epithelial cells; Polarized cells; Type IV pili; Adherence; Cell cycle; DNA damage; Lactobacillus; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : N. meningitidis and N. gonorrhoeae are obligate human pathogens that colonize mucosal surfaces and are often carried asymptomatically. These bacteria have developed adhesive structures that promote adherence to host cells and efficient colonization of new hosts. LÄS MER

  2. 2. Antibacterial peptides - key players in host defense at epithelial surfaces

    Författare :Mette Eliasson; Lund Lungmedicin och Allergologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosa; epithelium; pharyngitis; Innate immunity; Streptococcus pyogenes; antibacterial peptides; IFN-gamma; CXCL9 MIG; chemokines;

    Sammanfattning : Innate host defense mechanisms at epithelial surfaces are important to prevent bacterial invasion. Streptococcus pyogenes, group A streptococcus (GAS), has an affinity for epithelial cells and cause pharyngitis. During streptococcal pharyngitis, high concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were found in tonsil fluid. LÄS MER

  3. 3. Midkine - a host defence protein

    Författare :Sara Nordin; Lund Lungmedicin och Allergologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial polypeptides; Midkine; antibacterial; antifungal; innate immunity; epithelial surfaces;

    Sammanfattning : Every day we encounter many potentially harmful microbes in our environment. The epithelial linings constitute an anatomical barrier protecting us and they also produce antimicrobial polypeptides (AMPs) that act as a chemical barrier. These AMPs are small and positively charged, killing a broad range of microbes rapidly. LÄS MER

  4. 4. Interplay between bacteria and host epithelial cells

    Författare :Lisa Maudsdotter; Ann-Beth Jonsson; Cindy Grove Arvidson; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Microbial-cell interaction; Adherence; Infection; Lactic acid bacteria; Antimicrobial peptides; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Bacterial pathogens have developed multiple ways of manipulating host cell functions to exploit the host environment. We found that interactions with epithelial cells increase the resistance of the human pathogen Neisseria meningitidis to the antimicrobial peptide LL-37. LÄS MER

  5. 5. The human antimicrobial peptide hCAP18 in epithelial defense

    Författare :Margareta Frohm Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Innate immunity; host defense; antimicrobial peptide; hCAP 18; LL-37; epithelia; wounds; breast cancer;

    Sammanfattning : Gene-encoded antimicrobial peptides serve a protective role in host defense. They are multifunctional effector molecules in innate immunity - the nonadaptive immune system -with the capacity to kill a broad spectrum of microorganisms. LÄS MER