Sökning: "epithelial barrier"

Visar resultat 1 - 5 av 129 avhandlingar innehållade orden epithelial barrier.

  1. 1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers

    Författare :Staffan Tavelin; Per Artursson; Staffan Tavelin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; intestinal epithelium; tight junctions; cell culture; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. LÄS MER

  3. 2. Airway epithelial shedding: Morphological and functional aspects in vivo

    Författare :Jonas Erjefält; Luftvägsinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; eosinophils; neutrophils; plasma exudation; barrier restitution; basal cells; ciliated cells; secretory cells; Epithelial repair; epithelial shedding; fibrinogen; fibronectin; Respiratory system; Andningsorganen;

    Sammanfattning : Epithelial damage may contribute to the pathology in airway diseases such as asthma and rhinitis. However, the distribution of epithelial shedding in inflammatory airway diseases and, particularly, the ensuing repair processes are largely unknown. LÄS MER

  4. 3. Perturbation of the epithelial barrier by enteric pathogens

    Författare :Farideh Tafazoli; Magnusson Karl-Eric; Hakon Leffler; Linköpings universitet; []
    Nyckelord :enteric pathogens: signal transduction; barrier function; MEDICINE; MEDICIN;

    Sammanfattning : Gastrointestinal infections in humans have been associated with a number of diseased condition, including stomach ulcers, gastroenteritis, Crohn's disease, and rheumatic arthritis. Such infections often cause altered intestinal permeability through perturbation of the tight junctions that hold epithelial cells together. LÄS MER

  5. 4. Epithelial barrier dysfunction in ileal Crohn's disease

    Författare :Johan Dabrosin-Söderholm; Svante Nordgren; Linköpings universitet; []
    Nyckelord :acetylsalicylic add; confocal microscopy; Crohn s disease; cytoskeleton; electron microscopy; genetics; human; ileum; inflammatory bowel disease; intestinal absorption; intestinal mucosa; macromolecules; mitochondria; ovalbumin; permeability; sodium caprate; tight junctions; transcytosis; uncoupling agents; Ussing chamber; MEDICINE; MEDICIN;

    Sammanfattning : The study aimed at investigating the intestinal barrier in Crohn's disease, with special reference to epithelial responses to luminal stimuli, and to permeation of proteins.Ileal mucosa from patients undergoing intestinal resection was studied in vitro in Ussing chambers. LÄS MER

  7. 5. Epithelial barrier protection : implications for HIV susceptibility

    Författare :Gabriella Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The majority of HIV infections today occur through sexual HIV transmission. The female genital mucosa offers a barrier against incoming pathogens. Although, studies show that the vaginal microbiome, co-current infections and local inflammation, the use of hormonal contraceptives and microbicides, can weaken this protective lining. LÄS MER