Sökning: "epigenome"

Visar resultat 1 - 5 av 40 avhandlingar innehållade ordet epigenome.

  1. 1. The Control of the Epigenome

    Författare :Magda Lezcano; Rolf Ohlsson; Matthias Merkenschlager; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biology; Epigenetics; chromosome interactions; replication timing; histone modifications; epigenetic surveillance; Biologi; Biology; Biologi;

    Sammanfattning : The genetic information required for the existence of a living cell of any kind is encoded in the sequence information scripted in the double helix DNA. A modern trend in biology struggles to come to grip with the amazing fact that there are so many different cell types in our body and that they are directed from the same genomic blueprint. LÄS MER

  3. 2. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation

    Författare :Alba Atienza Párraga; Helena Jernberg-Wiklund; Fredrik Öberg; Antonia Kalushkova; Miguel Angel Peinado; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; epigenetics; Polycomb; EZH2; miRNA; DNA methylation; inhibitor.; Experimentell patologi; Experimental Pathology;

    Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER

  4. 3. Array-based Genomic and Epigenomic Studies in Healthy Individuals and Endocrine Tumours

    Författare :Johanna Sandgren; Gunnar Westin; Teresita Diaz de Ståhl; Göran Åkerström; Ola Hessman; Winand Dinjens; Uppsala universitet; []
    Nyckelord :genome; copy number variants; cancer; Pheochromocytoma; epigenome; array-CGH; ChIP-chip; gene expression; tumour suppressor genes; oncogenes; MEDICINE; MEDICIN; Kirurgi; Surgery;

    Sammanfattning : The human genome is a dynamic structure, recently recognized to present with significant large-scale structural variation. DNA-copy number changes represent one common type of such variation and is found both between individuals and within the somatic cells of the same individual, especially in disease states like cancer. LÄS MER

  5. 4. Role of GPS2 in epigenome alterations linked to metaflammation

    Författare :Zhiqiang Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current evidence suggests that transcriptional and epigenomic reprogramming events, triggered by transcription factors and chromatin-modifying co-regulators, are of central importance for disease development. G-protein pathway suppressor 2 (GPS2) is a key component of the HDAC3 co-repressor complex that has been earlier implicated in cholesterol homeostasis and anti-inflammatory crosstalk. LÄS MER

  7. 5. The Impact of Our Lifestyle on the Epigenome and Metabolism

    Författare :Josefine Jönsson; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epigenetik; Livsstil; Kost; Fysisk aktivitet; WGBS; DNA metylering; Fetma; Graviditet; Avkomma; Sperma; Humana pankreas öar; Navelsträngsblod; Muskel massa; Tillväxt; Födelsevikt; Genexpression; Fertilitet; Human hälsa; Typ 2 diabetes; Epigenetics; Lifestyle; Physical activity; Diet; WGBS; DNA methylation; Obesity; Pregnancy; Offspring; Sperm; Human islets; Cord blood; Lean mass; Growth; Birthweight; Gene expression; Fertility; Human health; Type 2 Diabetes;

    Sammanfattning : .... LÄS MER