Sökning: "epigenetics"

Visar resultat 16 - 20 av 110 avhandlingar innehållade ordet epigenetics.

1. 16. Overlapping Neural Substrates of Alcohol- and Anxiety-Related Behavior in the Rat

   Författare :Riccardo Barchiesi; Estelle Barbier; Markus Heilig; Annika Thorsell; Andrew Holmes; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alcohol use disorder; Anxiety disorder; Behavior; Rat; Prelimbic cortex; Amygdala; Basolateral amygdala; Stress; Epigenetics; Syt1; Prdm2; Avp; Conditioned fear; Social defeat stress; Witness stress; Susceptibility; Resilience;

   Sammanfattning : Alcohol use is a leading cause of death and disease worldwide. A large part of this disease burden is associated with alcohol use disorder (AUD), a diagnostic category characterized by excessive use in spite of negative consequences ("compulsive use"), a loss of control over intake, and choice of alcohol over natural rewards. LÄS MER

3. 17. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

   Författare :Igor Bazov; Georgy Bakalkin; Catharina Lavebratt; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuropeptides; dynorphin; human brain; alcohol dependence; epigenetics; gene transcription;

   Sammanfattning : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. LÄS MER

4. 18. The role of nuclear envelope proteins in chromatin organization, differentiation and disease

   Författare :Cecilia Bergqvist; Einar Hallberg; Philippe Collas; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope proteins; chromatin organization; epigenetics; differentiation; quantitative image analysis; Samp1; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : In eukaryotes the genetic material is separated from the cytoplasm by the nuclear envelope (NE), consisting of the outer and inner nuclear membrane, the nuclear lamina and the nuclear pores. The genetic material is highly structured with transcriptionally inactive heterochromatin enriched at the nuclear periphery and transcriptionally active euchromatin in the nuclear interior. LÄS MER

5. 19. The role of nuclear membrane proteins in differentiation and chromatin organization

   Författare :Cecilia Bergqvist; Einar Hallberg; Neus Visa; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; nuclear membrane proteins; chromatin organization; epigenetics; differentiation; stem cells; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The nuclear envelope, consisting of an outer and an inner nuclear membrane, surrounds the genomic material. The genomic material (chromatin) is highly structured with (transcriptionally inactive) heterochromatin mostly found in the nuclear periphery and (transcriptionally active) euchromatin mostly found in the nuclear interior. LÄS MER

7. 20. Epigenetic Regulation of Replication Timing and Signal Transduction

   Författare :Rosita Bergström; Aristidis Moustakas; Carl-Henrik Heldin; Rolf Ohlsson; Alain Mauviel; Uppsala universitet; []
   Nyckelord :Cell and molecular biology; Chromatin; CTCF; Epigenetics; Genomic Imprinting; H19; Id; Igf2; Insulator; Replication; Signal Transduction; Smad; TGF-β; Transcription; Cell- och molekylärbiologi;

   Sammanfattning : Upon fertilization the paternal and maternal genomes unite, giving rise to the embryo, with its unique genetic code. All cells in the human body are derived from the fertilized ovum: hence they all contain (with a few exceptions) the same genetic composition. LÄS MER