Sökning: "epigenetic"
Visar resultat 6 - 10 av 379 avhandlingar innehållade ordet epigenetic.
6. Suppressor of zeste 12, a Polycomb group gene in Drosophila melanogaster; one piece in the epigenetic puzzle
Sammanfattning : In multicellular organisms all cells in one individual have an identical genotype, and yet their bodies consist of many and very different tissues and thus many different cell types. Somehow there must be a difference in how genes are interpreted. So, there must be signals that tell the genes when and where to be active and inactive, respectively. LÄS MER
7. Towards forecasting epigenetic repression
Sammanfattning : Multicellular organisms form many different cell types from one genome, which requires differential gene activity. The Polycomb system upholds the correct gene expression programs by epigenetically silencing genes that encode critical transcription regulators. LÄS MER
8. Epigenetic Regulation by Noncoding RNA
Sammanfattning : High throughput transcriptomic analyses have realized us with the fact that eukaryotic genome encodes thousands of noncoding RNAs (ncRNAs) with unknown function. In my thesis, I sought to address epigenetic regulation of transcription by ncRNA using the Kcnq1 imprinted cluster as a model system. LÄS MER
9. Genetic and Genomic Analysis of Transcriptional Regulation in Human Cells
Sammanfattning : There are around 20.000 genes in the human genome all of which could potentially be expressed. However, it is obvious that not all of them can be active at the same time. Thus, there is a need for coordination achieved through the regulation of transcription. LÄS MER
10. The elephant in the cell : A multifaceted undertaking to uncover the molecular principles behind lymphatic endothelial cell identity
Sammanfattning : The lymphatic vascular network is composed of a series of blind ended vessels, and is involved in physiological functions such as fluid homeostasis, lipid metabolism and immune trafficking. Despite lymphatic endothelial cells being derived from multiple organs, they share common molecular denominators, including the expression of the transcription factor Prox1. LÄS MER