Sökning: "epigenetic"
Visar resultat 16 - 20 av 379 avhandlingar innehållade ordet epigenetic.
16. Epigenetic mechanisms of asthma and allergy
Sammanfattning : Allergic diseases such as atopic eczema (AE) and asthma are chronic inflammatory disorders in which the regulation of the immune system is altered, in concert with disease-specific defects in target organs. Their inception requires gene-environment interactions but the molecular mechanisms contributing to the pathogenesis remain unclear. LÄS MER
17. Heritable epigenetic responses to environmental challenges : Effects on behaviour, gene expression and DNA-methylation in the chicken
Sammanfattning : Phenotypic variation within populations is a crucial factor in evolution and is mainly thought to be driven by heritable changes in the base sequence of DNA. Among our domesticated species we find some of the most variable species on earth today. LÄS MER
18. Genetic and epigenetic alterations in melanoma
Sammanfattning : Malignant melanoma is a disease that may arise in several different parts of the body, preferentially the skin, rarely in the mucosal membranes or the choroidal tissues of the eye. The incidence of cutaneous melanoma (CMM) is steadily increasing in the Caucasian populations, unlike uveal melanoma (UM) that shows a stable incidence. LÄS MER
19. Genetic and Epigenetic Characterisation of Breast Tumours
Sammanfattning : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. LÄS MER
20. Epigenetic regulation of transcription and cellular development
Sammanfattning : Epigenetic machinery can regulate different biological processes via different mechanisms. In this thesis, we explore the effects of the epigenetic system on transcription and how it can differ during cellular development in different human cell lines models, with focus on hematopoiesis. LÄS MER
