Sökning: "epidermal growth factor"

Visar resultat 21 - 25 av 180 avhandlingar innehållade orden epidermal growth factor.

  1. 21. Growth factor receptor signalling in thyrocytes of normal and neoplastic origin

    Författare :Daniel Bergström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; thyroid; carcinoma; HGF; Met; TGF-β; EGF; receptor signalling; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Cellular growth and function are controlled by stimulatory and inhibitory factors actingthrough specific receptors. The present thesis focuses on the role of growth factors, theirreceptors and signalling pathways in normal and neoplastic thyroid epithelial cell biology. LÄS MER

  3. 22. Cbl in Regulation of Growth Factor Receptor Endocytosis and Actin Dynamics

    Författare :Iwona Szymkiewicz; Ivan Dikic; Silvia Giordano; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; RTK; Cbl; endocytosis; ubiquitination; actin; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : Proteins belonging to the Cbl family are multidomain scaffolds that participate in numerous processes, assembling signaling complexes and mediating attachment of ubiquitin to receptor and non-receptor tyrosine kinases.We characterized a novel role for Cbl and Cbl-b in ligand-dependent internalization of growth factor receptors. LÄS MER

  4. 23. GH Secretion in children. Methodological aspects of determining immunoreactive and bioactive isoforms

    Författare :Chatarina Löfqvist; Göteborgs universitet; []
    Nyckelord :Growth hormone; immunoassay; cross-reactivity; standard; antibody; insulin-like growth factor 1; reference values;

    Sammanfattning : A child's hormone-dependent growth is dependent on multiple factors, although linear growth is closely associated with levels of growth hormone (GH) secretion. As GH in serum exists in several isoforms, some of which may not be identified by immunoassay, possible alterations in the secretion of these different isoforms in childhood may influence growth and/or metabolism. LÄS MER

  5. 24. Dynamics and gene expression of growth factor receptors in human cultured skin cells : Effects of UV radiation and calcium on EGF- and PDGF-receptors

    Författare :Margareta Lirvall; Gunnar Kratz; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Growth factors transmit biological signals for the stimulation of cell growth and their stimulation may be involved in turnourigenesis. It is therefore of great importance to understand growth factor receptor reactions in response to stimuli such as calcium depletion or ultraviolet radiation, which normal human cells are invariably exposed to during their growth cycle. LÄS MER

  7. 25. Current Medical Treatment of Endocrine Pancreatic Tumors and Future Aspects

    Författare :Marie-Louise Fjällskog; Morten Vatn; Uppsala universitet; []
    Nyckelord :Medical sciences; pancreatic tumors; somatostatin analogs; cisplatin; etoposide; somatostatin receptors; immunohistochemistry; tyrosine kinase receptors; platelet-derived growth factors receptors PDGFRs ; c-kit; epidermal growth factor receptor EGFR ; MEDICIN OCH VÅRD; alfa-interferon; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : We treated 16 patients with somatostatin analogs combined with α-interferon and achieved a biochemical and/or radiological response in 56% (median duration 22 months). We consider this treatment a good alternative for patients who fail during chemotherapy or who do not want to/cannot receive cytotoxic drugs. LÄS MER