Sökning: "epidermal growth factor"

Visar resultat 11 - 15 av 180 avhandlingar innehållade orden epidermal growth factor.

  1. 11. Transforming growth factor a in human hematopoietic cells

    Författare :Thomas M. Walz; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : TGF-a, transforming growth factor a, is a potent growth factor belonging to the family of EGF (epidermal growth factor) -related proteins. Binding to the same receptor as EGF it has a ubiquitous repertoire of target cells, including, mesenchymal, epithelial and neuronal cells. LÄS MER

  3. 12. Affibody molecules targeting the epidermal growth factor receptor for tumor imaging applications

    Författare :Mikaela Friedman; Stefan Ståhl; Fredrik Nilsson; James S. Huston; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; affinity maturation; phage display selection; EGFR; molecular imaging; protein engineering; tumor targeting; Bioengineering; Bioteknik;

    Sammanfattning : Tumor targeting and molecular imaging of protein markers specific for or overexpressed in tumors can add useful information in deciding upon treatment and assessing the response to treatment for a cancer patient. The epidermal growth factor receptor (EGFR) is one such tumor-associated receptor, which expression is abnormal or upregulated in various cancers and associated with a poor patient prognosis. LÄS MER

  4. 13. Midgut Carcinoid Tumours : New Diagnostic Procedures and Treatment

    Författare :Staffan Welin; Eva T. Janson; Barbro Eriksson; Larry Kvols; Uppsala universitet; []
    Nyckelord :Medicine; Midgut carcinoid tumour; Chromogranin A; Carcinoid heart disease; Survival; Octreotide pamoate; Tyrosine kinase receptors; Platelet derived growth factor receptor; Epidermal growth factor receptor; Medicin;

    Sammanfattning : Midgut carcinoid tumours are rare with an incidence of 0.5-2.1/100 000. The primary tumour is usually small and grows slowly but has almost always set metastases at diagnosis. LÄS MER

  5. 14. Targeting Human Epidermal Growth Factor Receptors with Drug Conjugates Based on Affibody Molecules

    Författare :Jie Zhang; Torbjörn Gräslund; Per-Åke Nygren; Marika Nestor; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecule; HER2; HER3; affibody-drug conjugate; half-life; payload; Affibody-molekyl; HER2; HER3; affibody-läkemedelskonjugat; halveringstid; nyttolast; Biotechnology; Bioteknologi;

    Sammanfattning : Cancer is a major public health challenge and the second leading cause of death in the world, with millions of new cases being diagnosed each year. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy are many times effective, but may also cause damage to healthy cells, leading to side effects. LÄS MER

  7. 15. Molecular Probing of Local Protein-Protein Interactions : Studies of the tissue factor, factor VIIa complex formation

    Författare :Maria Österlund; Mikael Oliveberg; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Protein-protein interactions are intrinsic to virtually all cellular processes. However, very little is known about the dynamics of the formation of protein complexes or the order of events that direct the association between two protein molecules (the association pathway), especially when different interacting surfaces are involved. LÄS MER