Sökning: "enzyme models"
Visar resultat 1 - 5 av 233 avhandlingar innehållade orden enzyme models.
1. Towards Classification and Functional Description of Enzymes: A case study of feruloyl esterases
Sammanfattning : The prediction of enzyme functionality from sequence or structure data remains a challenging task that can be best addressed by studying the structure-function relationships determined from previously available information. This thesis work was focused on developing a reliable classification and functional description for the feruloyl esterase (FAE) enzyme family, whose members’ possess both structural and catalytic promiscuity. LÄS MER
2. Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease
Sammanfattning : Parkinson’s disease is a brain disorder characterized by loss of dopaminergic neurons in the midbrain, resulting in the characteristic motor symptoms: resting tremor, rigidity, akinesia and postural instability. Symptomatic treatment is based on reconstituting the loss of dopamine in the brain, primarily by oral administration of its precursor L-DOPA. LÄS MER
3. Novel Regulators of Brain Tumor Development : – From neural stem cell differentiation to in vivo models
Sammanfattning : Malignant brain tumors are diseases with poor prognosis and/or severe long-term side effects of treatment. This thesis aimed to discover novel regulators in brain tumor development, based on studying neural stem cell and progenitor cell (NSPC) differentiation and using animal models to introduce new insights to mechanisms of human brain tumors. LÄS MER
4. Amperometric Biosensors for Detection of Analytes in Cellular Models
Sammanfattning : Various biological problems such as disease mechanisms, drug development and toxicological studies motivated the introduction of cellular models that today also represent an alternative for reducing the use of animals in controversial medical and pharmaceutical experiments. Cells are complex matrices where several processes occur simultaneously. LÄS MER
5. Computational modelling of enzyme selectivity
Sammanfattning : Enantioselective reactions are one of the ways to produce pure chiral compounds. Understanding the basis of this selectivity makes it possible to guide enzyme design towards more efficient catalysts. LÄS MER