Sökning: "enzymatic cascade"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden enzymatic cascade.

1. 1. Transaminase Biocatalysis: Applications and Fundamental Studies

   Författare :Federica Ruggieri; Per Berglund; Mariarita Bertoldi; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; biocatalysis; enzymatic cascade; transaminase; amine; racemization; PLP; enzyme engineering; Chromobacterium violaceum; protein stability; enzyme stability; molecular dynamics; structural biology; enzyme technology; chiral amines; kinetic resolution; Bioteknologi; Biotechnology;

   Sammanfattning : Biocatalysis is the branch of science at the intersection between chemistry and biology and specifcally dedicated to the application of natural evolvable catalysts, i.e. enzymes, in human-designed chemical processes. Among the array of promising biocatalysts, transaminases (EC 2. LÄS MER

3. 2. Dynamic Systems : Enzymatic Synthesis, Exchange Reactions and Applications in Materials Science

   Författare :Yang Zhang; Olof Ramström; Mihail D. Barboiu; KTH; []
   Nyckelord :constitutional dynamic chemistry; reversible reactions; kinetic resolution; dynamic kinetic resolution; enzyme catalysis; lipase; asymmetric synthesis; racemization; oxazolidinone; organogel; enamine; nitroaldol reaction.;

   Sammanfattning : This thesis is divided into three parts, revolving around the developments of dynamic systems utilized in dynamic kinetic resolution (DKR) and constitutional dynamic chemistry (CDC).The first section gives an introduction to constitutional dynamics, the core concept of this thesis. LÄS MER

4. 3. Lipid Nanotube Networks: Shape Transitions and Insights into the Dynamics of Self-Organization

   Författare :Tatsiana Lobovkina; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; circular nanotube; shape transition; enzymatic reaction; nanotube knot; self-organization; liposome; lipid nanotube; lipid vesicle; nanotube-vesicle network;

   Sammanfattning : Nanotube-vesicle networks (NVNs) are simplified models of cell membrane tubular systems which are dynamic transportation routs for molecular cargoes in biological cells. The presented work describes dynamic properties of NVNs such as self-organization, shape and topology transformations; moreover, specific geometric properties of the networks are used for controlling enzymatic reactions. LÄS MER

5. 4. Chemo-enzymatic cascades for the synthesis of chiral high-value chemicals

   Författare :Lisa Marx; Per Berglund; Sabine Flitsch; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

   Sammanfattning : Chiral amines are frequent in today´s top selling pharmaceuticals. Classical organic synthesis of pharmaceuticals is often work intensive involving many synthesis steps, the use of protection group chemistry, heavy metal catalysts and chiral crystallization techniques. LÄS MER

7. 5. Rational engineering of esterases for improved amidase specificity in amide synthesis and hydrolysis

   Författare :Peter Hendil-Forssell; Mats Martinelle; Romas J. Kazlauskas; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Amidase; Biocatalysis; Enzyme; Esterase; Enzyme engineering; Lipase; Substrate specificity; Bioteknologi; Biotechnology;

   Sammanfattning : Biocatalysis is an ever evolving field that uses enzymes or microorganisms for chemical synthesis. By utilizing enzymes that generally have evolved for specific reactions under mild conditions and temperatures, biocatalysis can be a more environmentally friendly option compared to traditional chemistry. LÄS MER